Evidence map›Paper›PMID 42611059›Full record

ReviewMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026

Zidesamtinib (Jideytro®): a new selective, brain-penetrant ROS1 inhibitor approved for the treatment of ROS1-positive non-small cell lung cancer.

Sumi Lee, Longqin Hu

Abstract readReview
In one paragraph

Review in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sumi LeeSchool of Pharmacy and Institute of New Drug Development, Jeonbuk National University, Jeonju, 54907, Republic of Korea. chsmath27@jbnu.ac.kr.ORCID 0000-0002-2257-0798
Longqin HuDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuy sen Road, Piscataway, NJ 08854, Rutgers, USA.ORCID 0000-0002-1799-5652

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ROS1-targeted therapies have improved outcomes in ROS1-positive non-small cell lung cancer (NSCLC), but acquired resistance, CNS progression, and off-target toxicities remain important limitations. Zidesamtinib (Jideytro

Indexed as

Antineoplastic AgentsBrainCarcinoma, Non-Small-Cell LungLung NeoplasmsProtein Kinase InhibitorsProto-Oncogene ProteinsTyrosine Kinase InhibitorsAnimalsHumansProtein-Tyrosine KinasesAntineoplastic AgentsProtein Kinase InhibitorsProtein-Tyrosine KinasesProto-Oncogene ProteinsROS1 protein, humanTyrosine Kinase InhibitorsG2032Rnon-small cell lung cancerROS1Zidesamtinib

Identifiers

PMID42611059
PMCPMC13538244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.