ArticlemSystems2026
Transcriptional regulation drives heteroresistance in
Weijie Feng, Jia Hou, Gang Li, He Yin, Tiantian Dang, Guangqi Li, Jiaming Li, Min Li, Chunhua Song, Sean X Leng and 1 more
Abstract read
In one paragraphArticle in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Jia Hou *Department of Respiratory and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Gang LiMedical Laboratory Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
He YinMedical Laboratory Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Tiantian DangMedical Laboratory Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Guangqi LiMedical Laboratory Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Jiaming LiMedical Laboratory Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Min LiCentral Laboratory, Peking University First Hospital Ningxia Women and Children's Hospital (Ningxia Hui Autonomous Region Maternal and Child Health Hospital), Yinchuan, Ningxia, China.
Chunhua SongDivision of Hematology, The Ohio State University Wexner Medical Center, The James Cancer Hospital, Columbus, Ohio, USA.ORCID 0000-0002-4081-2543 Sean X LengJohns Hopkins Center on Aging and Immune Remodeling, Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-2690-8055 Zhijun ZhaoCentral Laboratory, Peking University First Hospital Ningxia Women and Children's Hospital (Ningxia Hui Autonomous Region Maternal and Child Health Hospital), Yinchuan, Ningxia, China.ORCID 0000-0002-8044-6648 Funding
Milstein Medical Asian American Partnership FoundationNatural Science Foundation of Ningxia Province 2024AAC03696Science and Technology Department of Ningxia Province 2024FRD05043
6 · The paper itselfAbstract
Bacterial heteroresistance, characterized by the presence of antibiotic-resistant subpopulations within phenotypically susceptible bacterial colonies, poses significant challenges to clinical antimicrobial susceptibility testing and treatment outcomes. While heteroresistance has been increasingly recognized across diverse bacterial species, the underlying mechanisms in
Indexed as
Drug Resistance, BacterialGene Expression Regulation, BacterialPseudomonas aeruginosaAnti-Bacterial AgentsBacterial ProteinsGene Expression ProfilingGenomicsHumansMicrobial Sensitivity TestsPseudomonas InfectionsAnti-Bacterial AgentsBacterial ProteinsheteroresistancePseudomonas aeruginosaresistance mechanismstranscriptional regulationtwo-component system
Identifiers
PMID42610700
PMCPMC13595920
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