Evidence map›Paper›PMID 42610521›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer.

Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei and 4 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaoting LiuDepartment of Gastrointestinal Surgery, School of Medicine, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Chong WuDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Shiyao SongDepartment of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Li MaDepartment of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, China.
Shaoqing HuangDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yuting HeDepartment of Gastrointestinal Surgery, School of Medicine, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Qinghai LiDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yanzhou ChangDepartment of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, China.
Dan JiangDepartment of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, China.
Yong MeiDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Junchao CaiDepartment of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Zhenshuang DuDepartment of Gastrointestinal Surgery, School of Medicine, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Tianfeng ChenDepartment of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0001-6953-1342
Weiling HeDepartment of Gastrointestinal Surgery, School of Medicine, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.

Funding

Fujian Provincial Health and Medical High-Level Talent Team XM050005Key-Area Research and Development Program of Guangdong Province 2023B1111020005National Natural Science Foundation of China 82472087National Natural Science Foundation of China 92359302Natural Science Foundation for Outstanding Youth Team Project of Guangdong Province 2024B1515040030Natural Science Foundation of Fujian Province 2024J011004
6 · The paper itself

Abstract

Despite substantial progress in KRAS-targeted therapies, specific inhibitors of the KRAS G13D mutant remain unavailable. In a retrospective analysis, we found a notable downregulation of glutathione peroxidase 2 (GPX2) in KRAS G13D- mutant colorectal cancer (CRC), which correlated with poor outcomes. We hypothesized that GPX2 acts as a tumor suppressor and that its restoration could render KRAS G13D-driven tumors vulnerable. In this study, we developed a selenium nanoparticle (SeNPs)-based nanostrategy to suppress KRAS G13D-driven tumors by modulating GPX2 expression. SeNPs upregulated GPX2 expression, thereby inhibiting metastasis through the GPX2-HIF1α-VEGF axis. Moreover, SeNPs release selenite (SeO

Indexed as

colorectal cancerGPX2KRAS mutantnanoparticlesselenium metabolism

Identifiers

PMID42610521
PMCPMC13483143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.