Evidence map›Paper›PMID 42610500›Full record

ArticleChemistry, an Asian journal2026

Palladium-Catalyzed Fluoroallylation of Aldimine Esters With gem-Difluorocyclopropanes: Synthesis of Fluorinated α-Amino Acid Derivatives.

Jia-Wei Tang, Kaiyang Xu, Junqi Su, Zili Chen, Leiyang Lv

Abstract read
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Article in Chemistry, an Asian journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Jia-Wei TangKey Laboratory of Advanced Light Conversion Materials and Biophotonics, School of Chemistry and Life Resources, Renmin University of China, Beijing, People's Republic of China.
Kaiyang XuKey Laboratory of Advanced Light Conversion Materials and Biophotonics, School of Chemistry and Life Resources, Renmin University of China, Beijing, People's Republic of China.
Junqi SuKey Laboratory of Advanced Light Conversion Materials and Biophotonics, School of Chemistry and Life Resources, Renmin University of China, Beijing, People's Republic of China.
Zili ChenKey Laboratory of Advanced Light Conversion Materials and Biophotonics, School of Chemistry and Life Resources, Renmin University of China, Beijing, People's Republic of China.
Leiyang LvKey Laboratory of Advanced Light Conversion Materials and Biophotonics, School of Chemistry and Life Resources, Renmin University of China, Beijing, People's Republic of China.ORCID https://orcid.org/0000-0002-2850-8952

Funding

Beijing Natural Science Foundation 2252010Fundamental Research Funds for the Central UniversitiesNational Natural Science Foundation of China 22571319Qiushi Academic Project of Renmin University of China RUC25QSDL134the Research Funds of Renmin University of China 202530195the Research Funds of Renmin University of China 24XNKJ27
6 · The paper itself

Abstract

Traditional approaches to α-C─H bond functionalization of aldimine esters heavily rely on bimetallic catalysis. In this work, we report a method for the fluoroallylation of aldimine esters using gem-difluorocyclopropanes under single palladium catalysis. This strategy enables the diversity-oriented synthesis of various fluorinated α-amino acid derivatives in good to excellent yields. The key fluorinated aldimine esters were formed via sequential α-C─H deprotonation and fluoroallylation. Subsequent in situ acidic hydrolysis afforded the corresponding free amino acid esters, while reduction with NaBH

Indexed as

aldimine estersfluoroallylationgem‐difluorocyclopropanespalladium catalysisα‐amino acid

Identifiers

PMID42610500
PMCPMC13482843

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