Evidence map›Paper›PMID 42610328›Full record

ArticleThe Journal of physiology2026

Photosensitive response mouse model: A potential tool for studying mechanisms of photosensitive epilepsy and initial screening of anti-epileptic drugs.

Menghua Li, Xinyu Long, Xu Wang, Doudou Zhao, Ziye Jia, Qing Li, Hehua Wang, Ziyi Chen, Dandan Chen, Yan Jia and 10 more

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Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Menghua LiDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xinyu LongDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xu WangInstitute of Neurology, Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Doudou ZhaoDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Ziye JiaDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID https://orcid.org/0009-0009-4912-6388
Qing LiDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Hehua WangDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Ziyi ChenInstitute of Neurology, Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Dandan ChenDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yan JiaDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jingyan ChaiDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Mei LiuJiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Zhaojun HuangDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Ruifang HuaHenan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Xin FangDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Wen-Quan ZouInstitute of Neurology, Department of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Yingqiong XiongDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yuanjian YangNanchang City Key Laboratory of Biological Psychiatry, Health Commission of Jiangxi Province Key Laboratory of Psychiatry, Jiangxi Provincial Clinical Research Center on Mental Disorders, Jiangxi Mental Hospital (Affiliated Mental Hospital), Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Daojun HongDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Pengcheng HuangDepartment of Neurology, Rare Disease Center, Key Laboratory of Rare Neurological Diseases of Jiangxi Province Health Commission, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID https://orcid.org/0000-0002-8532-5570

Funding

China National University Student Innovation & Entrepreneurship Development Program of Xinxiang Medical University 202410472007Key Laboratory Project of Neurological Diseases in JiangxiKey Scientific and Technological Projects of Henan 242102310372National Natural Science Foundation of China 82201674National Natural Science Foundation of China 82260268National Natural Science Foundation of China 82271439National Natural Science Foundation of China 82271557Natural Science of Foundation of Jiangxi Province 20224BAB216044Natural Science of Foundation of Jiangxi Province 20232BAB206069
6 · The paper itself

Abstract

Numerous studies have investigated the mechanisms underlying photosensitive epilepsy, yet they remain poorly understood. Progress in this field has been substantially hampered by the scarcity of valid animal models and the difficulty in establishing them. Here we presented flashing lights at varying frequencies to head-fixed mice while recording local field potentials (LFPs) in the primary visual cortex (V1). We identified approximately 5 Hz as the resonant frequency for eliciting photosensitive responses. By modulating the luminance within the behavioural chamber we found that the response amplitude diminished with reduced stimulus contrast. Dual-region LFP recordings revealed that the photosensitive response propagated to the medial prefrontal cortex (mPFC), with the response in V1 being both stronger and earlier than those in the mPFC. Acute treatment with pentylenetetrazole (PTZ) enhanced the photosensitive response in V1, whereas chronic PTZ treatment did not. Furthermore we demonstrated that several anti-epileptic drugs effectively attenuated the photosensitive response in both V1 and mPFC. Collectively our findings establish a murine photosensitivity model as a promising platform for the investigation of the mechanisms underlying photosensitive epilepsy and for the initial screening of potential antiepileptic therapeutics. KEY POINTS: The resonant frequency of the photosensitive response in mice is approximately 5 Hz. Photosensitive response decreases as the stimulus contrast reduces, and its response to red light is weaker than that to white light. The photosensitive response can propagate to the medial prefrontal cortex (mPFC) region but does not induce clinical epileptic seizures. Some anti-epileptic drugs can alleviate the photosensitive response.

Indexed as

AnticonvulsantsDisease Models, AnimalEpilepsy, ReflexPrimary Visual CortexAnimalsLocal Field Potential MeasurementMaleMiceMice, Inbred C57BLPentylenetetrazolePhotic StimulationPrefrontal CortexAnticonvulsantsPentylenetetrazoleflashing lightsphotosensitive epilepsyscreening antiepileptic drugs

Identifiers

PMID42610328
PMCPMC13532922

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.