Evidence map›Paper›PMID 42610126›Full record

ArticleProteoglycan research2026

MMP2 sheds Glypican-4 to suppress Slit3-Robo4 signaling and angiogenesis.

Wenyuan Xiao, Alexander R Orta, Jingwen Yue, Xuehong Song, Huquan Yin, Lianchun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteoglycan research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenyuan XiaoDepartment of Molecular Pharmacology & Physiology, University of South Florida, 4001 E. Fletcher Ave., Tampa, FL33613, USA.
Alexander R OrtaDepartment of Molecular Pharmacology & Physiology, University of South Florida, 4001 E. Fletcher Ave., Tampa, FL33613, USA.
Jingwen YueDepartment of Molecular Pharmacology & Physiology, University of South Florida, 4001 E. Fletcher Ave., Tampa, FL33613, USA.
Xuehong SongDepartment of Molecular Pharmacology & Physiology, University of South Florida, 4001 E. Fletcher Ave., Tampa, FL33613, USA.
Huquan YinDepartment of Molecular Pharmacology & Physiology, University of South Florida, 4001 E. Fletcher Ave., Tampa, FL33613, USA.
Lianchun WangDepartment of Molecular Pharmacology & Physiology, University of South Florida, 4001 E. Fletcher Ave., Tampa, FL33613, USA.

Funding

Robo4 and heparan sulfate proteoglycan in angiogenesisR01HL093339 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI WANG, LIANCHUN · 2009 to 2018
$3.4M
Heparan sulfate proteoglycan in the brain vascular clearance of amyloid-β and Alzheimer's diseaseRF1AG074289 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI WANG, LIANCHUN · 2021 to 2021
$1.8M
Basolateral brain endothelial cilia and its role in promoting vascular stabilityR01HL179583 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Ramani Ramchandran, Lianchun Wang · 2025 to 2026
$1.3M
Heparan sulfate proteoglycan in the brain vascular clearance of amyloid-β and Alzheimer's diseaseR01AG074289 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI WANG, LIANCHUN · 2024 to 2025
$1.2M
NHLBI NIH HHS R01 HL093339NHLBI NIH HHS R01 HL179583NIA NIH HHS R01 AG074289NIA NIH HHS RF1 AG074289
6 · The paper itself

Abstract

Axon guidance molecules, initially identified for their roles in neural development, are now recognized as crucial regulators of angiogenesis and blood vessel patterning. Among these, Slit3 promotes endothelial cell migration, proliferation, and vascular network formation by signaling through the endothelial-specific receptor Robo4. This interaction depends on heparan sulfate (HS) as a co-receptor for assembly of the Slit3-Robo4 complex, although the specific HS proteoglycan involved has not yet been identified. Our recent work also shows that Robo4 ectodomain shedding by ADAM10 and ADAM17 suppresses this angiogenic pathway. Here, we identify matrix metalloproteinase-2 (MMP2) as an additional suppressor of Slit3-Robo4 signaling.

Indexed as

angiogenesisGPC4MMP2Robo4Slit3

Identifiers

PMID42610126
PMCPMC13480415

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.