Life-Threatening Spontaneous Retroperitoneal Hemorrhage Associated with Acenocoumarol Anticoagulation in a Young Patient with a Mechanical Aortic Valve: A Case Report.

Background: Spontaneous retroperitoneal hemorrhage is an uncommon but potentially fatal complication of anticoagulant therapy. Management is particularly difficult in patients with mechanical heart valves because urgent reversal must be balanced against the risk of valve thrombosis and systemic embolism. Case Presentation: A 24-year-old man with a mechanical aortic valve receiving acenocoumarol presented with severe abdominal pain, abdominal distension, and syncope. Hemoglobin was 4 g/dL, serum creatinine was 2.5 mg/dL, and the international normalized ratio was 15. Contrast-enhanced computed tomography showed a large left perinephric retroperitoneal hematoma extending into the left iliopsoas muscle and pelvis, without hemoperitoneum or active contrast extravasation. Acenocoumarol was stopped, and he received intravenous vitamin K, fresh frozen plasma because prothrombin complex concentrate was unavailable, packed red blood cells, and intensive monitoring. He improved without invasive intervention, and anticoagulation was cautiously reintroduced after clinical and radiological stabilization. Conclusion: Spontaneous retroperitoneal hemorrhage should be considered in anticoagulated patients with abdominal or flank pain, syncope, unexplained anemia, hypotension, or acute kidney injury. Prompt diagnosis, urgent reversal, and individualized anticoagulation resumption are essential.