Encapsulate bacteria in implantable hydrogels for living therapeutics.

Rui Guo, Zhaoqi Duan, Ganghao Liang, Xiujun Fan, Jun Chen

Abstract read

In one paragraph

Article in Matter, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rui GuoDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Zhaoqi DuanDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Ganghao LiangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Xiujun FanDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Jun ChenDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Funding

Magnetoelastic Vascular GraftsR01HL175135 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jun Chen · 2025 to 2026

$1.1M

A soft magnetoelastic microneedle patch for rapid skin cancer screeningR01CA287326 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jun Chen · 2024 to 2026

$1.1M

NCI NIH HHS R01 CA287326NHLBI NIH HHS R01 HL175135

6 · The paper itself

Abstract

Recent advances in implantable living materials have highlighted their potential for autonomous therapeutic delivery by integrating mechanically robust hydrogels with encapsulated therapeutic bacteria. By enabling long-term biocontainment, environmental sensing, and genetically programmed drug release within physiologically stable scaffolds, these living materials establish a versatile foundation for next-generation personalized therapeutics and closed-loop disease management.

Identifiers

PMID42610123

DOI10.1016/j.matt.2026.102962

PMCPMC13480410

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.