ArticleAdvanced functional materials2021
Photon Upconversion Hydrogels for 3D Optogenetics.
Article in Advanced functional materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Reversible Supramolecular Hydrogel for Air-Tolerant Photon Upconversion: Key Development for Photocatalyst Recovery and Product Extraction in Aqueous Medium.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Intermediate Electronic Coupling via Silane and Germane Bridges in Silicon Quantum Dot-Molecular Hybrid Systems.Nano letters · 2025Article
- Confinement-Enhanced Multi-Wavelength Photon Upconversion Based on Triplet-Triplet Annihilation in Nanostructured Glassy Polymers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Tetherless Optical Neuromodulation: Wavelength from Orange-red to Mid-infrared.Neuroscience bulletin · 2024Review
- Multifold Enhanced Photon Upconversion in a Composite Annihilator System Sensitized by Perovskite Nanocrystals.ACS nano · 2024Article
- Articular cartilage repair biomaterials: strategies and applications.Materials today. Bio · 2024Review
- Promoting multiexciton interactions in singlet fission and triplet fusion upconversion dendrimers.Nature communications · 2023Article
- Optogenetic approaches in biotechnology and biomaterials.Trends in biotechnology · 2022Review
- Article
- Microfluidic oxygen tolerability screening of nanocarriers for triplet fusion photon upconversion.Journal of materials chemistry. C · 2022Article
- Approaching the Spin-Statistical Limit in Visible-to-Ultraviolet Photon Upconversion.Journal of the American Chemical Society · 2022Article
- Red Light Optogenetics in Neuroscience.Frontiers in cellular neuroscience · 2021Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The ability to optically induce biological responses in 3D has been dwarfed by the physical limitations of visible light penetration to trigger photochemical processes. However, many biological systems are relatively transparent to low-energy light, which does not provide sufficient energy to induce photochemistry in 3D. To overcome this challenge, hydrogels that are capable of converting red or near-IR (NIR) light into blue light within the cell-laden 3D scaffolds are developed. The upconverted light can then excite optically active proteins in cells to trigger a photochemical response. The hydrogels operate by triplet-triplet annihilation upconversion. As proof-of-principle, it is found that the hydrogels trigger an optogenetic response by red/NIR irradiation of HeLa cells that have been engineered to express the blue-light sensitive protein Cry2olig. While it is remarkable to photoinduce the clustering of Cry2olig with blanket NIR irradiation in 3D, it is also demonstrated how the hydrogels trigger clustering within a single cell with great specificity and spatiotemporal control. In principle, these hydrogels may allow for photochemical control of cell function within 3D scaffolds, which can lead to a wealth of fundamental studies and biochemical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.