Evidence map›Paper›PMID 42610116›Full record

ArticleGastroenterology report2026

Development and validation of a Bayesian network-based surgical risk-prediction tool for patients with small-bowel stricturing Crohn's disease.

Weijie Chen, Chuanding Li, Mengfan Chen, Chunhui Ouyang, Chunyan Peng, Xiaoqi Zhang, Zhiqiang Cai, Meiying Zeng, Xiaolei Wang

Abstract read
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Article in Gastroenterology report, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Weijie ChenDepartment of Gastroenterology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R. China.ORCID https://orcid.org/0000-0002-6370-7615
Chuanding LiDepartment of Gastroenterology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R. China.
Mengfan ChenDepartment of Gastroenterology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R. China.
Chunhui OuyangDepartment of Gastroenterology, The Second Xiangya Hospital of Central South University, Hunan, 410011, P. R. China.
Chunyan PengDepartment of Gastroenterology, Nanjing Drum Tower Hospital of Nanjing University, Nanjing, 210008, P. R. China.
Xiaoqi ZhangDepartment of Gastroenterology, Nanjing Drum Tower Hospital of Nanjing University, Nanjing, 210008, P. R. China.
Zhiqiang CaiSchool of Mechanical Engineering, Northwestern Polytechnical University, Shanxi, 710072, P. R. China.
Meiying ZengDepartment of Radiology, Shanghai Tenth People's Hospital Chongming Branch, School of Medicine, Tongji University, Shanghai, 202150, P. R. China.
Xiaolei WangDepartment of Gastroenterology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R. China.ORCID https://orcid.org/0000-0003-2023-6670

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with small-bowel stricturing Crohn's disease (sbsCD) usually have a higher risk of intestinal surgical resection. We aimed to develop a machine-learning model for predicting the 1-year surgery risk in these patients. Methods: This study included 520 retrospectively enrolled patients with sbsCD (training cohort, Results: There were 158 (24.4%) Crohn's disease (CD)-related surgeries during the 1-year follow-up. Eight selected predictors of surgery included penetrating lesions, nonuse of biologics, nonuse of corticosteroids, a CD obstructive score of ≥3, endoscopic strictures, anemia, radiologic luminal narrowing, and prestenotic dilation. Among the six models evaluated, the Tree-Augmented Naïve Bayes (TAN) model demonstrated optimal performance, with a mean AUC of 0.878. A further prospective validation cohort verified the efficacy of the model, with 87.5% specificity, 76.7% sensitivity, and 84.9% accuracy for predicting 1-year surgery. Four simplified BN-based risk matrices were constructed for practical use. An online prediction tool is available at http://prebn.site/. Conclusion: We developed and validated a TAN-based BN model incorporating clinical and radiological features to accurately predict the 1-year surgical risk for clinical application in patients with sbsCD, thereby providing a promising tool for decision-making.

Indexed as

Bayesian networkCrohn’s diseaseprediction toolsmall-bowel stricturesurgical risk

Identifiers

PMID42610116
PMCPMC13480436

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.