Evidence map›Paper›PMID 42610093›Full record

ArticlePain reports2026

Effects of

Steven E Harte, Lesley M Arnold, Eric Ichesco, Scott J Peltier, Kim M Cecil, Chelsea M Kaplan, Brock Pluimer, Apeksha Sridhar, Tony E Larkin, Andrew D Schrepf and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Steven E HarteChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0002-2929-8694
Lesley M ArnoldWomen's Health Research Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Eric IchescoChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Scott J PeltierFunctional Magnetic Resonance Imaging Laboratory, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Kim M CecilDepartment of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Chelsea M KaplanChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Brock PluimerSusan Samueli Integrative Health Institute, School of Medicine, University of California Irvine, Irvine, CA, USA.
Apeksha SridharSusan Samueli Integrative Health Institute, School of Medicine, University of California Irvine, Irvine, CA, USA.
Tony E LarkinChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Andrew D SchrepfChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Joseph R MoskalFalk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, USA.
Daniel J ClauwChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Torsten M MadsenIama Therapeutics, Genoa, Italy.
Richard E HarrisChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This exploratory, 2-site phase 2 clinical trial investigated whether neuroimaging biomarkers could demonstrate the analgesic potential of NYX-2925, a novel Methods: Twenty-two participants completed sequential 2-week treatment periods: placebo, 20 mg NYX-2925, and 200 mg NYX-2925. Resting state functional connectivity magnetic resonance imaging and proton magnetic resonance spectroscopy were performed during the second week of each period. Results: The 200 mg dose produced statistically significant improvements in pain, fatigue, fibromyalgia severity, and function compared with placebo. Neuroimaging revealed that NYX-2925 reduced glutamate and glutamine/total creatine ratios in the dorsal anterior cingulate cortex at rest ( Conclusion: These exploratory findings suggest that NYX-2925 modulates excitatory neurometabolic activity and functional connectivity in pain-processing networks, with modest accompanying clinical improvement. A subsequent larger randomized trial did not confirm clinical benefit, so the present results should be regarded as hypothesis-generating and require independent replication. We discuss the value, and the limits, of neuroimaging measures for mechanistic drug development and personalized pain medicine.

Indexed as

FibromyalgiaFunctional connectivityGlutamateNeuroimagingNMDA receptorNociplastic pain

Identifiers

PMID42610093
PMCPMC13480845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.