ArticleIranian journal of basic medical sciences2026
Effects of glucocorticoid on cardiac chronotropic responsiveness in cirrhotic rats: A possible role for dopamine receptors.
Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Cirrhosis causes chronotropic dysfunction by weakening the β-adrenergic receptor (β-AR) signaling pathway in cirrhotic cardiomyopathy (CCM). Downstream signaling of glucocorticoids and dopamine receptors influences the β-AR pathway. Thus, the effects of glucocorticoids on chronotropic incompetence and the possible involved pathways were investigated in this experiment. Materials and Methods: Bile duct ligation (BDL) surgery was performed on Wistar rats to induce cirrhosis. Four weeks after BDL or sham surgery, the subjects were given an intramuscular injection of either saline (NS) or dexamethasone (dexa) (2.2 mg/kg/day) for three consecutive days. Results: Dexa treatment reduced the prolonged QT intervals in cirrhosis. It also dedcreasd spleen weight, as well as TNF-α levels, which are increased in cirrhosis. Moreover, dexa increased D1 protein expression in IHC. Conclusion: Dexa effectively improved cirrotic heart by improving QT intervales and increasing spleen weight, reducing a pro-inflammatory cytokine, and up-regulateing D1 receptor protein expression.
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