ArticleJournal of extracellular biology2026
Altered MicroRNA Signatures in Circulating Extracellular Vesicles Reflect Aortic Dilation in Takayasu Arteritis.
Article in Journal of extracellular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Takayasu arteritis (TAK) is a large-vessel vasculitis that can lead to aneurysmal dilation, yet reliable circulating biomarkers for vascular remodelling remain lacking. Extracellular vesicles (EVs) carry miRNAs implicated in vascular biology, but their relevance to TAK has not been fully explored. Circulating EVs were isolated from serum of 54 patients with TAK and healthy controls (HC), characterized, and profiled for miRNA content. Effects on endothelial cells (ECs) and monocytes were examined in vitro, and the diagnostic performance of EV-associated miR-223-3p for aortic dilation was assessed by ROC analysis. Circulating EVs from patients with TAK exhibited a distinct miRNA profile compared with HC. HC-EVs reduced the transcript abundance of
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