Evidence map›Paper›PMID 42610066›Full record

ArticleSeparation and purification technology2025

Investigation of Magnetic Nanoparticle Recovery using a Quadrupole Magnetic Field via Numerical Simulation and SAXS.

Xian Wu, Hyeon Choe, Stefano Ciannella, Karla Mercedes Paz Gonzalez, Linh Nguyen T Tran, Poornima Ramesh Iyer, Bennett A Yunker, Ioannis H Karampelas, Kai Wu, Maciej Zborowski and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Separation and purification technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Magnetic nanoparticles for cancer theranostics.Biomedical physics & engineering express · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xian WuWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210.
Hyeon ChoeWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210.
Stefano CiannellaDepartment of Chemical Engineering, Texas Tech University, Lubbock, Texas 79409.
Karla Mercedes Paz GonzalezDepartment of Chemical Engineering, Texas Tech University, Lubbock, Texas 79409.
Linh Nguyen T TranDepartment of Chemical Engineering, Texas Tech University, Lubbock, Texas 79409.
Poornima Ramesh IyerWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210.
Bennett A YunkerDavis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio 43210.
Ioannis H KarampelasNemak USA, Inc., Sheboygan, WI 53081, United States.
Kai WuDepartment of Electrical and Computer Engineering, Texas Tech University, Lubbock, Texas 79409.
Maciej ZborowskiDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195.
Barbara WyslouzilWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210.
Jeffrey ChalmersWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210.
Jenifer Gomez-PastoraDepartment of Chemical Engineering, Texas Tech University, Lubbock, Texas 79409.

Funding

Fractionation of Aged RBCs Based on Hemoglobin ContentR01HL131720 · NHLBI · OHIO STATE UNIVERSITY · PI CHALMERS, JEFFREY JOHN, PALMER, ANDRE FRANCIS · 2017 to 2020
$2.7M
NHLBI NIH HHS R01 HL131720
6 · The paper itself

Abstract

Magnetic nanoparticles (MNPs) have recently attracted considerable attention for various chemical and biomedical applications due to their unique properties. However, their separation from liquid solutions through magnetophoresis is challenging, as Brownian forces play a significant role when the particle size decreases below 50 nm. In this study, we investigate the separation of 27.5 nm superparamagnetic iron oxide nanoparticles (SPIONs) using a quadrupole magnetic sorter (QMS) with high magnetic field gradients. Small-angle X-ray scattering (SAXS) was employed to track SPION manipulation, revealing migration in specific directions and absence of aggregation outside the field, demonstrating the particle's superparamagnetic behavior. Although the QMS exerted radial magnetophoretic forces, SPIONs also exhibited axial movement upon their removal from the magnetic field. COMSOL simulation results agreed with our experimental findings, providing insights into the axial magnetic forces that the particles were subjected to during the process. This combined SAXS and simulation approach offers valuable insights for designing novel separation systems able to isolate small nanomaterials from liquid suspensions.

Indexed as

Magnetic nanoparticles (MNPs)magnetophoresisnumerical simulationsmall angle x-ray scattering (SAXS)superparamagnetic iron oxide nanoparticles (SPIONs)

Identifiers

PMID42610066
PMCPMC13480336

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.