ArticleACS polymers Au2026
Reversible Cationic Glycopolymer Hydrogels for RNA Delivery in Ticks.
Article in ACS polymers Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
RNA interference (RNAi) offers a promising approach for vector control in species such as the lone star tick (Amblyomma americanum), but current delivery methods, including microinjection and soaking, are invasive and inefficient for large-scale application. In this work, we developed a series of novel physically cross-linked cationic glycopolymer hydrogels for noninvasive double-stranded RNA (dsRNA) delivery and evaluated their rheological properties, release behavior, and in vivo performance. Rheological characterization demonstrated shear-thinning and self-healing behavior conducive to sprayable applications, while release studies revealed tunable cargo delivery dependent on glycomonomer stereochemistry and cationic content. In vivo studies showed that cationic terpolymer hydrogels successfully traversed the peritrophic membrane and enabled tissue-specific gene silencing, including in ovarian tissue. These findings establish a promising platform for sprayable RNAi delivery and provide a framework for the design of targeted gene delivery systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.