Evidence map›Paper›PMID 42609988›Full record

ArticlePeerJ2026

Enhanced digestion and absorption kinetics of ultra-low molecular weight collagen containing di- and tripeptides: evidence from human and cell models.

Reyhan Nergiz-Unal, Stephan Dierckx, Chiara Roye, Yingying Wu, Faye Maertens, David Pajuelo Gamez, Marian Merino, Jose Luis Mullor, Bengu Depboylu, Carlos Daniel Mandolesi

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In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Reyhan Nergiz-UnalTessenderlo Innovation Center, Tessenderlo Group NV, Brussels, Belgium.
Stephan DierckxTessenderlo Innovation Center, Tessenderlo Group NV, Brussels, Belgium.
Chiara RoyePB Leiner, Part of Tessenderlo Group, Brussels, Belgium.
Yingying WuPB Leiner, Part of Tessenderlo Group, Brussels, Belgium.
Faye MaertensTessenderlo Innovation Center, Tessenderlo Group NV, Brussels, Belgium.
David Pajuelo GamezFaculty of Health Sciences, Universidad Europea de Valencia, Valencia, Spain.
Marian MerinoBionos Biotech SL., LabAnalysis Life Science, Valencia, Spain.
Jose Luis MullorBionos Biotech SL., LabAnalysis Life Science, Valencia, Spain.
Bengu DepboyluFaculty of Medicine, Adnan Menderes University, Aydın, Turkiye.
Carlos Daniel MandolesiPB Leiner, Part of Tessenderlo Group, Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Collagen hydrolysates differ in molecular weight distribution and composition, which may influence gastrointestinal absorption and epithelial transport. Objective: The objective of this study is to compare the digestion and absorption kinetics of an ultra-low molecular weight collagen with >45% di- and tripeptides (LMWCP; 500 Da) and a standard collagen hydrolysate (CP; 2,000-3,000 Da) using a Caco-2 cell model and an exploratory human study. Materials and methods: A Caco-2 cell Transwell model was used to assess the apical-to-basolateral appearance of collagen-derived free amino acids over 240 minutes after Results: In both models, LMWCP showed faster early-phase kinetics than CP. In the Caco-2 model, collagen-derived amino acids appeared in the basolateral compartment within the first minutes and were highest during the first 30 minutes with LMWCP. In the human study, plasma glycine and proline/hydroxyproline peaked earlier after LMWCP group (30 minutes) compared to CP group (120 minutes). Conclusion: Across both

Indexed as

CollagenDigestionDipeptidesIntestinal AbsorptionOligopeptidesAdultAmino AcidsBioactive Peptides, DietaryCaco-2 CellsHumansKineticsMaleMolecular WeightProtein HydrolysatesYoung AdultAmino AcidsBioactive Peptides, DietaryCollagenDipeptidesOligopeptidesProtein HydrolysatesBioavailability of di- and tripeptidesCaco-2 cell modelCollagen hydrolysateFood supplementHuman plasmaUltra-low molecular weight collagen peptides

Identifiers

PMID42609988
PMCPMC13480140

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.