Evidence map›Paper›PMID 42609973›Full record

ArticleBiomedical optics express2026

Unambiguous polarimetric reconstruction in single-input polarization-sensitive OCT via spectral polarization spreading.

Georgia L Jones, Maxina Sheft, Jiachen Wan, Po-Yi Lee, Hui Wang, Brett E Bouma, Martin Villiger

Abstract read
In one paragraph

Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Georgia L JonesWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0002-1657-5912
Maxina SheftWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Jiachen WanAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Po-Yi LeeWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Hui WangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Brett E BoumaWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Martin VilligerWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0003-3819-1271

Funding

TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Brett E Bouma · 2012 to 2026
$22.4M
Neuroimaging Training ProgramT32EB001680 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BRUCE R ROSEN · 2003 to 2026
$3.8M
Universal optical coherence polarimetryR01EB033321 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI VILLIGER, MARTIN · 2022 to 2025
$2.0M
NIBIB NIH HHS P41 EB015903NIBIB NIH HHS R01 EB033321NIBIB NIH HHS T32 EB001680
6 · The paper itself

Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) systems employing a single polarized input state are widely used due to their simple system architecture and commercial availability. However, such configurations are inherently susceptible to polarization ambiguities that can lead to inaccurate polarimetric reconstruction, particularly when estimating depth-resolved birefringence. Our previous work demonstrated that these artifacts can be mitigated by illumination exhibiting spectral polarization spread (SPS), arising from polarization mode dispersion present in some imaging systems. SPS effectively provides additional polarization diversity across the source spectrum, reducing ambiguity in the measured retardance signals. In this work, we introduce a compact waveplate stack module that introduces controlled, intentional SPS in arbitrary single-input PS-OCT systems. We demonstrate the approach by integrating the module into the round-trip portion of the sample arm of a commercially available PS-OCT platform, enabling robust and unambiguous depth-resolved polarimetric reconstruction. The minimal hardware modification and simple calibration procedure allow straightforward retrofitting of existing single-input PS-OCT systems, facilitating broader adoption of reliable, depth-resolved birefringence imaging.

Identifiers

PMID42609973
PMCPMC13481092

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.