Evidence map›Paper›PMID 42609935›Full record

ArticleSexual medicine2026

Validation of the Turkish version of the ANDROTEST for detecting male hypogonadism in patients with sexual dysfunction.

Abdullah Akdag, Enes Aktas, Akif Erbin, Batu Akalin, Halil Lutfi Canat

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Article in Sexual medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Abdullah AkdagUniversity of Health Sciences, Department of Urology, Basaksehir Cam Sakura City Hospital, Istanbul, 34480, Turkey.ORCID https://orcid.org/0000-0001-9281-0913
Enes AktasUniversity of Health Sciences, Department of Urology, Basaksehir Cam Sakura City Hospital, Istanbul, 34480, Turkey.ORCID https://orcid.org/0009-0007-5237-8661
Akif ErbinUniversity of Health Sciences, Department of Urology, Basaksehir Cam Sakura City Hospital, Istanbul, 34480, Turkey.ORCID https://orcid.org/0000-0001-7147-8288
Batu AkalinUniversity of Health Sciences, Department of Urology, Basaksehir Cam Sakura City Hospital, Istanbul, 34480, Turkey.ORCID https://orcid.org/0000-0001-7570-1862
Halil Lutfi CanatUniversity of Health Sciences, Department of Urology, Basaksehir Cam Sakura City Hospital, Istanbul, 34480, Turkey.ORCID https://orcid.org/0000-0001-6481-7907

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Male hypogonadism is an important endocrine cause of sexual dysfunction, yet symptom-based screening tools require cultural and linguistic validation to ensure their reliability across different populations. Aim: To evaluate the diagnostic performance, reliability, and validity of the Turkish version of the ANDROTEST in men presenting with sexual dysfunction. Methods: This prospective observational study included men aged 18-80 years presenting to the andrology outpatient clinic with symptoms of sexual dysfunction between February and November 2025. A control group consisted of age-matched individuals without clinical suspicion of hypogonadism or conditions affecting gonadal function. Participants completed the Turkish versions of Beck Depression Inventory (BDI) and the International Index of Erectile Function (IIEF). The ANDROTEST was translated and culturally adapted using a forward-backward translation process. Diagnostic performance was evaluated using receiver operating characteristic curve analysis, while test-retest reliability was assessed using the intraclass correlation coefficient (ICC). Multivariable logistic regression analysis was performed to identify independent predictors of hypogonadism. Outcomes: The primary outcome was the diagnostic performance of the Turkish ANDROTEST for identifying hypogonadism. Results: A total of 246 participants were included (120 controls and 126 patients with hypogonadism). Hypogonadal patients demonstrated significantly higher body mass index, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and BDI, whereas total testosterone, free testosterone, sex hormone-binding globulin, high-density lipoprotein cholesterol, IIEF scores, and testicular volumes were significantly lower (all Clinical Implications: The Turkish version of the ANDROTEST may serve as a practical screening tool for identifying men at risk of hypogonadism in routine clinical practice. Strengths and Limitations: Strengths include the prospective design and comprehensive evaluation of psychometric and diagnostic performance. Limitations include the single-center design and the case-control structure, which may overestimate diagnostic performance. Conclusion: The Turkish version of the ANDROTEST demonstrated excellent diagnostic performance and strong reliability for identifying male hypogonadism in men with sexual dysfunction, supporting its potential utility as a culturally adapted screening tool in clinical practice.

Indexed as

erectile dysfunctionhypogonadismmalequestionnairessensitivity and specificity

Identifiers

PMID42609935
PMCPMC13480882

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.