ArticleLaryngoscope investigative otolaryngology2026
Microbiota and Mycobiota Dysbiosis in Sinonasal Fungus Ball: A Paired Lesional and Contralateral Analysis.
Article in Laryngoscope investigative otolaryngology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Fungus ball (FB) is a unilateral form of fungal rhinosinusitis, but it remains unclear whether associated microbial dysbiosis is restricted to the lesional sinus or extends across the sinonasal cavity. This study aimed to determine whether bacterial and fungal dysbiosis in maxillary sinus FB is spatially localized by comparing paired lesional and contralateral-normal sites within the same individuals. Methods: This prospective paired-sample study enrolled 14 adults with surgically confirmed unilateral maxillary sinus FB at a tertiary referral center. Middle-meatal swabs were obtained from lesional and contralateral-normal sides during endoscopic sinus surgery. Bacterial and fungal communities were profiled using 16S rRNA gene and internal transcribed spacer (ITS) sequencing. Alpha and beta diversity, taxonomic composition, predicted functional pathways, and bacterial-fungal co-occurrence networks were analyzed. Results: Lesional sinuses showed significantly reduced bacterial alpha diversity compared with contralateral-normal sides (Wilcoxon Conclusion: In this cohort, microbial dysbiosis in maxillary sinus FB appeared to be spatially localized, with patterns suggestive of anaerobe enrichment and ecological reorganization centered on Level of Evidence: 3.
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