Evidence map›Paper›PMID 42609799›Full record

ArticleEngineering research express2021

A magnetoelastic bone fixation device for controlled mechanical stimulation at femoral fractures in rodents.

Salil S Karipott, Karly Fear, Bradley Nelson, Kelly Leguineche, Angela Lin, Sudhanshu Shekhar, Robert E Guldberg, Keat Ghee Ong

Abstract read
In one paragraph

Article in Engineering research express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Salil S KaripottPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR 97403, United States of America.ORCID 0000-0002-5286-6047
Karly FearPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR 97403, United States of America.
Bradley NelsonPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR 97403, United States of America.
Kelly LeguinechePhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR 97403, United States of America.
Angela LinPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR 97403, United States of America.
Sudhanshu ShekharPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR 97403, United States of America.ORCID 0000-0001-8065-1599
Robert E GuldbergPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR 97403, United States of America.ORCID 0000-0002-0303-261X
Keat Ghee OngPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR 97403, United States of America.ORCID 0000-0003-2058-1028

Funding

Regenerative Rehabilitation of Complex Musculoskeletal InjuriesR01AR069297 · NIAMS · UNIVERSITY OF OREGON · PI ROBERT E Guldberg · 2016 to 2026
$5.6M
Mechanically Active Magnetoelastic System for Controlled Loading Environment to Promote Vascularized Bone RegenerationR15EB023648 · NIBIB · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI ONG, KEAT GHEE · 2017 to 2017
$468k
NIAMS NIH HHS R01 AR069297NIBIB NIH HHS R15 EB023648
6 · The paper itself

Abstract

Studies have shown that mechanical stimulations can provide anabolic bone formation and counteract conditions such as osteoporosis in intact bones, as well as promote healing of bone fractures. However, many of these studies are based on external mechanical loading platforms or bulky wearable force loading systems, which are inconvenient and impractical in clinical settings especially for the treatment of bone injuries. To overcome this limitation, a bone fixation device was developed to provide localized mechanical strains across a bone fracture site. The fixation device, designed for a rodent's femoral fracture (critical-size segmental defect), is consisted of a magnetoelastic (ME) actuator that changes its physical dimension when exposed to magnetic fields. The strain produced by the ME actuator is transferred to the bone fixation device, which acts directly on the bone-implant interface to produce a highly focused and localized mechanical loading. The actuation generated by the fixation device was evaluated, and results show the device was able to provide up to 150

Indexed as

low magnitude high frequency (LMHF)magnetoelastic actuatormechanical stimulationnonunion fractureorthopedic rehabilitationregenerative medicine

Identifiers

PMID42609799
PMCPMC13480060

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.