Evidence map›Paper›PMID 42609772›Full record

ArticleBeilstein journal of organic chemistry2026

A cascade synthesis of 2-aminothiochromones from 2-fluorophenyl ketone and thiocarbonyldiimidazole.

Kai Zhang, Haofan Shao, Kangjun Liao, Ying Xu, Shimei Du, Yanfang Zhao, Gang Li, Wenzhen Xu, Haihong Huang, Peng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kai Zhang *Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
Haofan Shao *Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China.
Kangjun Liao *Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China.
Ying XuQingdao BAHEAL Pharmaceutical Co., Ltd., Qingdao 266200, P. R. China.
Shimei DuQingdao BAHEAL Pharmaceutical Co., Ltd., Qingdao 266200, P. R. China.
Yanfang ZhaoKey Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
Gang LiInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China.ORCID https://orcid.org/0000-0003-0924-7950
Wenzhen XuQingdao BAHEAL Pharmaceutical Co., Ltd., Qingdao 266200, P. R. China.
Haihong HuangInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China.
Peng LiInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China.ORCID https://orcid.org/0000-0003-1626-3385

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A highly efficient cascade synthesis of various substituted 2-aminothiochromones was developed. The commercially available thiocarbonyldiimidazole (TCDI) acted as a key precursor in the construction of a sulfur-containing scaffold from 2-fluorophenyl ketone. Subsequent conjugated addition-elimination resulted in the corresponding 2-aminothiochromones under mild conditions. This simple protocol tolerates a broad range of functional groups and provides concise access to various 2-aminothiochromones in good to excellent yields (up to 94%).

Indexed as

cascade synthesisTCDIthiochromone

Identifiers

PMID42609772
PMCPMC13478896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.