Evidence map›Paper›PMID 42609758›Full record

ArticleWorld journal of otorhinolaryngology - head and neck surgery2026

Treatment of Severe Obstructive Sleep Apnea With a Domestic Implantable Hypoglossal Nerve Stimulator: A Case Report.

Su-Ru Liu, En-Hui Zhou, Xin-Yi Li, Hua-Jun Xu, Jian Guan, Hong-Liang Yi, Shan-Kai Yin

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In one paragraph

Article in World journal of otorhinolaryngology - head and neck surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Su-Ru LiuDepartment of Otorhinolaryngology Head and Neck Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otolaryngology Institute of Shanghai Jiao Tong University Shanghai China.ORCID https://orcid.org/0009-0007-2933-0870
En-Hui ZhouDepartment of Otorhinolaryngology Head and Neck Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otolaryngology Institute of Shanghai Jiao Tong University Shanghai China.ORCID https://orcid.org/0000-0001-8252-7778
Xin-Yi LiDepartment of Otorhinolaryngology Head and Neck Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otolaryngology Institute of Shanghai Jiao Tong University Shanghai China.
Hua-Jun XuDepartment of Otorhinolaryngology Head and Neck Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otolaryngology Institute of Shanghai Jiao Tong University Shanghai China.
Jian GuanDepartment of Otorhinolaryngology Head and Neck Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otolaryngology Institute of Shanghai Jiao Tong University Shanghai China.
Hong-Liang YiDepartment of Otorhinolaryngology Head and Neck Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otolaryngology Institute of Shanghai Jiao Tong University Shanghai China.
Shan-Kai YinDepartment of Otorhinolaryngology Head and Neck Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otolaryngology Institute of Shanghai Jiao Tong University Shanghai China.ORCID https://orcid.org/0000-0003-3689-8599

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Implantable hypoglossal nerve stimulation (HNS) is an established neuromodulatory therapy for obstructive sleep apnea (OSA) in patients intolerant to continuous positive airway pressure (CPAP). However, no domestically developed HNS system has been clinically implemented in China to date. Methods: We report the first clinical implantation of a novel, Chinese-developed HNS system in a patient with severe OSA. The patient was a 39-year-old man with a 20-year history of nocturnal snoring and apnea. Preoperative polysomnography (PSG) demonstrated an apnea-hypopnea index (AHI) of 46.3 events per hour and a lowest oxygen saturation of 83%. The device selectively activates the medial branch of the hypoglossal nerve, which induces genioglossus contraction and anterior tongue displacement, thereby stabilizing the upper airway during sleep. Results: The procedure was successfully performed. At short-term follow-up, the patient showed marked improvements: AHI decreased from 46.3 to 11.8 events/hour, LSaO Conclusions: This first‑in‑human experience confirms that the domestic HNS system is feasible, safe, and clinically effective in patient with severe OSA who is intolerant to CPAP. These preliminary results support further clinical development and validation of this domestically manufactured HNS technology for broader application in China.

Indexed as

domestic devicehypoglossal nerve stimulatorobstructive sleep apneaupper airway stimulation

Identifiers

PMID42609758
PMCPMC13478927

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.