ArticleFrontiers in allergy2026
Expanding grass pollen allergomes: benefits for the molecular profiling of products used for
Article in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Grass pollens are major outdoor sources of aeroallergens worldwide. Compared with timothy ( Methods: Grass pollen transcriptomes were sequenced. Results: Homologous counterparts of all timothy pollen allergens from groups 1-7 and 11-13 were found in all four other grass species studied. Varying degrees of sequence identity and similarity were observed, depending on the species and allergen group considered. Of the allergens that were successfully cloned and expressed, IgE reactivity was confirmed for nearly all recombinant protein. Additionally, novel allergens unrelated to the allergen groups studied were also identified. The enriched allergome information substantially enhanced the molecular resolution achieved in the characterization of diagnostic allergen products. Discussion: In-depth proteomics informed by transcriptomics enabled a major expansion of the pollen allergomes of the grass species studied. This extended allergomic knowledge, in turn, substantially improved the allergen characterization of
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