ArticleWorld journal of otorhinolaryngology - head and neck surgery2026
Hemodynamic Effects of Prolonged Apneic Oxygenation in Laryngologic Surgery: A Randomized Controlled Pilot Trial.
Article in World journal of otorhinolaryngology - head and neck surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Limited data exist on cardiocirculatory responses associated with extended periods of apnea during administration of high-flow nasal oxygen for laryngologic surgery (apneic oxygenation with HFNO, AO-HFNO). The possibility of hemodynamic compromise in the settings of acute hypercapnia, respiratory acidosis, hyperoxia, and IV anesthesia requires further investigation. This trial investigated the hemodynamic safety profile of prolonged AO-HFNO in adult patients undergoing laryngologic surgery. Methods: Using invasive hemodynamic monitoring, we conducted prospective, randomized, patient-blinded, two-arm parallel pilot trial in 20 adult patients (ASA physical status 1-3) undergoing elective laser laryngologic surgery expected to last over 40 min. The patients were randomly assigned to receive either AO-HFNO or conventional mechanical ventilation using a laser endotracheal tube (ETT). The primary outcome was the effect of prolonged permissive hypercapnia and IV anesthesia on intraoperative cardiocirculatory responses. Results: Extended AO-HFNO led to the development of moderate to severe hypercapnia with PaCO Conclusions: Prolonged AO-HFNO is associated with a safe intraoperative hemodynamic profile during extended periods of apnea for selected patients undergoing laryngologic surgery.
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