Evidence map›Paper›PMID 42609627›Full record

ArticleComprehensive Physiology2026

Targeting mTOR to Mitigate Sequelae of Chronic Hypoxia on the Carotid Artery and Cerebral Circulation.

Rira Choi, Jelena Mihailovic, Prapti Sharma, Fadi Nikola, Sydney L Bluestein, Pramath Doddaballapur, Nicole Guerrera, Nebal S Abu Hussein, Cristina Cavinato, Taylor S Adams and 5 more

Abstract read
In one paragraph

Article in Comprehensive Physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rira ChoiDepartment of Biomedical Engineering Yale University New Haven Connecticut USA.ORCID https://orcid.org/0000-0002-9759-6909
Jelena MihailovicDepartment of Diagnostic Radiology & Biomedical Imaging Yale University New Haven Connecticut USA.
Prapti SharmaSection of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine New Haven Connecticut USA.
Fadi NikolaSection of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine New Haven Connecticut USA.
Sydney L BluesteinSection of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine New Haven Connecticut USA.ORCID https://orcid.org/0009-0007-3731-1549
Pramath DoddaballapurUniversity of California Santa Barbara California USA.ORCID https://orcid.org/0009-0001-6691-2964
Nicole GuerreraDepartment of Medicine (Cardiovascular Medicine) Yale University New Haven Connecticut USA.
Nebal S Abu HusseinSection of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine New Haven Connecticut USA.ORCID https://orcid.org/0000-0001-6735-8435
Cristina CavinatoLMGC, University Montpellier CNRS Montpellier France.ORCID https://orcid.org/0000-0002-6021-8920
Taylor S AdamsSection of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine New Haven Connecticut USA.
Xiting YanSection of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine New Haven Connecticut USA.
Fahmeed HyderDepartment of Biomedical Engineering Yale University New Haven Connecticut USA.ORCID https://orcid.org/0000-0001-7822-4002
Peter HermanDepartment of Diagnostic Radiology & Biomedical Imaging Yale University New Haven Connecticut USA.ORCID https://orcid.org/0000-0003-2218-9652
Jay D HumphreyDepartment of Biomedical Engineering Yale University New Haven Connecticut USA.ORCID https://orcid.org/0000-0003-1011-2025
Edward P ManningSection of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine New Haven Connecticut USA.ORCID https://orcid.org/0000-0002-4430-8168

Funding

Graph Learning of Cell-cell Communications in Spatial TranscriptomicsR01LM014087 · NLM · YALE UNIVERSITY · PI WANG, ZUOHENG, YAN, XITING · 2022 to 2025
$1.5M
NLM NIH HHS R01 LM014087
6 · The paper itself

Abstract

We hypothesized that vascular maladaptations resulting from chronic hypoxemia worsen end-organ function via insidious positive feedback. To test this hypothesis in the systemic circulation, we quantified brain perfusion and left heart function and then biomechanically phenotyped the left common carotid artery (LCCA) in adult female mice under normoxic (21% oxygen) and chronic hypoxic (10%) conditions. Functional MRI revealed that hypoxia impaired cerebrovascular reactivity during transient hypercapnia (pCO

Indexed as

brainfMRIhypoxialungmultiorgan effectsrapamycinvascular biomechanics

Identifiers

PMID42609627
PMCPMC13478350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.