ArticleInfection and drug resistance2026
Daptomycin Overcomes
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Methods: Five Results: Daptomycin showed strain-dependent activity (MICs: 2-8 μg/mL), completely eradicating most persisters at 2×MIC within 24 hours (residual 4e survival: 0.5 log10 CFU/mL). Biofilm inhibition varied from 58% (1/2a) to complete resistance (4e). Transcriptomics revealed clpP as the most upregulated gene (5-7-fold in persisters), with concurrent mdrL induction (4.8-fold) and prfA suppression. Membrane genes (mprF/dltA) showed moderate upregulation (1-5-fold). Conclusion: Daptomycin effectively targets Listeria persisters, although efficacy varies by strain. The consistent clpP overexpression positions this protease as both a key persistence mediator and promising therapeutic target, potentially enhancing daptomycin-based interventions in food safety and clinical settings.
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