ArticleClinical case reports2026
Suspected Remifentanil-Induced Hyperalgesia in the ICU With Resolution After Opioid Rotation and no Recurrence on Re-Exposure: A Case Report.
Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Remifentanil-induced hyperalgesia should be considered in ICU patients with worsening pain despite dose escalation. Differentiation from acute opioid tolerance is crucial, as timely opioid rotation may rapidly restore analgesia and allow safe re-exposure to remifentanil without recurrence during later surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.