Evidence map›Paper›PMID 42609591›Full record

ArticleFrontiers in pharmacology2026

Computational analysis of therapeutic potential for simplified

B G Rice, B Wooton, C Jansen, J Howard, J Nixon, L Ellis, A Yasin, C N Adra, A J Stokes, S A Aporosa and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

B G RiceLaboratory of Pharmacology and Analytics, Biology and Data Science Programs, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, HI, United States.
B WootonLaboratory of Pharmacology and Analytics, Biology and Data Science Programs, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, HI, United States.
C JansenLaboratory of Pharmacology and Analytics, Biology and Data Science Programs, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, HI, United States.
J HowardLaboratory of Pharmacology and Analytics, Biology and Data Science Programs, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, HI, United States.
J NixonZebrafish Toxicology, Genomics and Neurobiology Team, National Research Council of Canada, Halifax, NS, Canada.
L EllisZebrafish Toxicology, Genomics and Neurobiology Team, National Research Council of Canada, Halifax, NS, Canada.
A YasinGB Global Biopharma, Las Vegas, Nevada, United States.
C N AdraThe Adra Institute, Boston, MA, United States.
A J StokesLaboratory of Experimental Medicine, Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, United States.
S A AporosaTe Huataki Waiora School of Health and Te Kura Whatu Oho Mauri School of Psychology, University of Waikato, Hamilton, New Zealand.
A L Small-HowardThe Adra Institute, Boston, MA, United States.
H TurnerLaboratory of Pharmacology and Analytics, Biology and Data Science Programs, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, HI, United States.

Funding

AIM-AHEAD Coordinating Center - All Four CoresOT2OD032581 · OD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Paul Avillach, Bettina M. Beech · 2021 to 2026
$168.7M
Cannabinoid and terpene regulation of nocioception and peripheral sensitization through ionotropic receptorsR15DA051749 · NIDA · CHAMINADE UNIVERSITY OF HONOLULU · PI TURNER, HELEN C · 2020 to 2020
$433k
NIDA NIH HHS R15 DA051749NIH HHS OT2 OD032581
6 · The paper itself

Abstract

Introduction: Phytomedicines have played a vital role in traditional medical systems globally, particularly in providing culturally relevant and accessible healthcare solutions. Methods: A new data platform aggregating non-Western phytomedical pharmacopeias was used to analyze the secondary metabolomes of various Results: Our findings suggest that while Kavalactones are predominantly unique to Discussion: These findings identify new potential avenues for exploration of phytomedical solutions to complex interconnected sleep, pain, stress, movement and anxiety issues that hallmark disorders such as PTSD and Parkinson's.

Indexed as

anxietykavaPiperPTSDsleeptraditional medicine

Identifiers

PMID42609591
PMCPMC13478742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.