ReviewFrontiers in cell and developmental biology2026
Beyond the convergence of metabolic reprogramming in primary liver cancer: a comprehensive review on energy and lipids metabolism.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hepatocellular carcinoma and cholangiocarcinoma, the most common primary liver cancers, are usually considered quite different pathologies. However, convergent metabolic reprogramming across different progenitor cells can result in similar molecular alterations and, even in a combined form of cancer that is characterized by transitional features and a shared phenotype. In this review, we summarize essential steps in glucose and lipid metabolism to distinguish similarities in glucose and energy metabolism reprogramming from divergent lipid remodeling in different types of primary liver cancers. We show the convergent nature of metabolic alterations in glucose decomposition and related mitochondrial enzymes. Also, we outline the essential role of lactate in promoting cell viability, adaptation to increased biomass synthesis, and fueling surrounding cancer cells to support their growth and proliferation. Lipid metabolism, in contrast, was found to be dramatically different between primary liver cancers. Hepatocellular carcinoma relies on
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