ArticleFrontiers in pediatrics2026
Prenatal MRI abdominal volumetrics and outcomes after early surgery or paint-and-wait for giant omphalocele.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Giant Omphalocele (GO) poses significant challenges in neonatal management. Standard treatment is paint-and-wait with delayed fascial closure at 1-2 years-of-age. Alternatively, early surgery entails neonatal sac removal with either primary fascial closure or staged GORE-TEX patch-assisted closure. We compared outcomes between early surgery and paint-and-wait and evaluated whether prenatal MRI volumetrics can identify candidates for primary closure. We performed a retrospective study (2007-2024) of newborns with GO (sac diameter ≥5 cm with liver). For early surgery patients, prenatal MRI volumetric analysis measured intra-abdominal (IAV) and eviscerated organ volumes (EOV) to generate a novel evisceration index (Evisceration Index = (EOV/(EOV + IAV)) × 100. Forty-three infants met inclusion (25 early, 18 paint-and-wait). Groups were similar for birth <34 weeks, weight, sac diameter, and associated anomalies. No patients required ECMO. Mortality was comparable (8.0% vs. 11.1%;
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