ArticleFrontiers in neuroscience2026
A user-friendly graphical user interface for paw touch classification in rodent cylinder testing.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In unilateral rodent models of disease or injury, deficits are induced in only one side of the body, allowing the difference in right versus left limb usage to serve as a metric of disease/injury severity and recovery with various treatments. Unilateral rat models are commonly used for conditions such as Parkinson's disease (via the neurotoxin 6-hydroxydopamine, 6-OHDA), stroke, and traumatic brain injury, as well as cervical spinal cord injury and peripheral nerve damage. The 'cylinder test' has been used for over two decades as a reliable metric of asymmetry in forelimb usage. In this test, videos are taken of the rodent in a vertical cylinder as it explores its surroundings. The experimenter then logs which forepaw was used to first touch the cylinder wall each time the animal reared up on its hind limbs to start a new wall exploration sequence. The process of manually scanning through videos and logging left/right paw touches can be very time consuming and prone to errors. To streamline this process, we made
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