ArticleFrontiers in pharmacology2026
Physician preferences for prescribing Chinese patent medicines during pregnancy: a discrete choice experiment.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Background: Prescribing Chinese patent medicines (CPMs) during pregnancy requires physicians to balance fetal safety, expected maternal benefit, patient preference, affordability, and limited pregnancy-specific evidence. Quantitative evidence on how these factors are traded off remains limited. Objective: To quantify physicians' preferences for prescribing CPMs during pregnancy, estimate the DCE-derived relative importance of key prescribing attributes, and explore preference patterns across physician subgroups. Methods: An unlabeled, forced-choice discrete choice experiment was conducted among physicians from a multi-tier medical consortium comprising 10 healthcare institutions in Anhui Province, China. Of 237 submitted questionnaires, 198 were retained for analysis, corresponding to a questionnaire validity rate of 83.54%. Seven attributes were included: fetal safety impact, treatment stage, patient willingness, prior prescribing experience with the specific CPMs, route of administration, patient affordability, and drug efficacy. A mixed logit model was used to estimate preference parameters and DCE-derived relative importance. Results: Compared with significant fetal impact, profiles indicating no fetal impact (β = 3.074, 95% CI 2.587 to 3.560, Conclusion: Fetal safety was the most influential attribute in physicians' choices between hypothetical CPMs profiles during pregnancy. Patient willingness, administration route, affordability, treatment stage, and efficacy also contributed to choices, whereas prior prescribing experience with the specific CPMs was not significantly associated with selection. The findings may inform evidence summaries, decision-support tools, and structured communication, but effects on actual prescribing and clinical outcomes require prospective evaluation.
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