Evidence map›Paper›PMID 42609302›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Multimodal assessment of liver stiffness and portal hemodynamics in a cirrhotic mouse model.

Jingtian Zhang, Yujie Huo, Jingxuan Bian, Li Cha, Qiyue Yang, Chunjuan Zhao, Jinyu Li, Dongliang Zhao, Duiping Feng, Long Gao

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Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jingtian ZhangDepartment of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Yujie HuoDepartment of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Jingxuan BianDepartment of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Li ChaDepartment of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Qiyue YangDepartment of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Chunjuan ZhaoDepartment of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Jinyu LiDepartment of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Dongliang ZhaoInstitute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.
Duiping FengDepartment of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Long GaoDepartment of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: Elevated pressure within the portal venous system defines portal hypertension. While extensive research has focused on its biochemical basis, the biomechanical characteristics of liver tissue in this condition remain largely unexplored. We established a carbon tetrachloride (CCl Methods: Portal hypertension was induced in six-week-old male BALB/c mice by intraperitoneal CCl Results: Collagen deposition was significantly and positively correlated with liver stiffness (r = 0.7232; p < 0.0001). Liver stiffness also correlated with the portal venous pulsatility index (r = 0.6477, p = 0.0005). Serum biomarkers, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), were positively correlated with liver stiffness (AST: r = 0.6596, p = 0.0016; ALT: r = 0.8451, p < 0.0001). Expression levels of α-smooth muscle actin (α-SMA) and Matrix Metallopeptidase-9 (MMP-9) were significantly associated with increased stiffness (α-SMA: r = 0.6837; p = 0.0002; MMP-9: r = 0.7365; p < 0.0001). Conclusion: In CCl

Indexed as

hepatic fibrosismechanobiologynon-invasive diagnosisportal hemodynamicssecond harmonic generation

Identifiers

PMID42609302
PMCPMC13478080

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.