Evidence map›Paper›PMID 42609241›Full record

ArticleFrontiers in immunology2026

Phenotypic and functional changes to porcine monocyte-derived macrophages triggered by IL-1β and its receptor antagonist IL-1Ra.

Emanuela Giaconi, Samanta Mecocci, Susanna Zinellu, Valentina Margarita, Sarah Morrone, Nicolò Columbano, Luisa Bogliolo, Sandra Barroso-Arévalo, Katia Cappelli, Giulia Franzoni

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emanuela GiaconiDepartment of Animal Health, Istituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy.
Samanta MecocciDepartment of Veterinary Medicine, University of Perugia, Perugia, Italy.
Susanna ZinelluDepartment of Animal Health, Istituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy.
Valentina MargaritaDepartment of Biomedical Science, University of Sassari, Sassari, SS, Italy.
Sarah MorroneDepartment of Veterinary Medicine, University of Sassari, Sassari, SS, Italy.
Nicolò ColumbanoDepartment of Veterinary Medicine, University of Sassari, Sassari, SS, Italy.
Luisa BoglioloDepartment of Veterinary Medicine, University of Sassari, Sassari, SS, Italy.
Sandra Barroso-ArévaloDepartment of Medicine and Animal Surgery, Faculty of Veterinary Medicine, Complutense University of Madrid, Madrid, Spain.
Katia CappelliDepartment of Veterinary Medicine, University of Perugia, Perugia, Italy.
Giulia FranzoniDepartment of Animal Health, Istituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pigs are attracting increasing attention as a large-animal model with translational relevance in biomedical research. They share several immunological similarities with humans, although the pig immune system has not been fully characterized yet, also at the level of macrophage polarization. A better understanding of porcine macrophage polarization could improve translational studies, allowing a better interpretation of

Indexed as

Interleukin-1betaInterleukin 1 Receptor Antagonist ProteinMacrophagesAnimalsCells, CulturedCytokinesMacrophage ActivationPhenotypeSwineCytokinesInterleukin-1betaInterleukin 1 Receptor Antagonist Proteincytokinesdomestic pigsinnate immunitymacrophagessurface markers

Identifiers

PMID42609241
PMCPMC13477873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.