Intervention methods and influencing factors of vitamin D deficiency in Northeast China: a self-controlled trial and randomized controlled trial study.

Junyi Liu, Chenyin Qu, Shanshan Jin, Yubing Jia, Lixin Na

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Junyi Liu *Department of Clinical Nutrition, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Chenyin Qu *College of Public Health, Shanghai University of Medicine and Health Sciences, Shanghai, China.

Shanshan JinDepartment of Nutrition, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Yubing JiaDepartment of Clinical Nutrition, Chongqing Hospital of Jiangsu Province Hospital, Chongqing, China.

Lixin NaCollege of Public Health, Shanghai University of Medicine and Health Sciences, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vitamin D deficiency is common among children in high-latitude regions. However, region-specific intervention strategies remain unclear. Few studies have simultaneously examined outdoor activity intervention, vitamin D supplementation, and genetic polymorphisms. Thus, this study aimed to explore feasible intervention strategies for children in Northeast China. Method: Sixty-one children were asked to increase outdoor activities for 8 weeks (June-August). Outdoor activity duration and ultraviolet (UV) intensity were recorded. Changes in serum 25(OH)D Results: Outdoor activity duration increased by 11 min/d, and estimated vitamin D production from UV increased by 60.73 IU/d, but serum 25(OH)D Conclusion: Increasing outdoor activity did not improve vitamin D status in children in Northeast China, but daily supplementation was effective. Dietary vitamin D intake and SNPs should be considered when formulating individualized supplementation doses.

Indexed as

childrensingle nucleotide polymorphismsultraviolet irradiationvitamin D deficiencyvitamin D supplementation

Identifiers

PMID42609231

DOI10.3389/fnut.2026.1778526

PMCPMC13477899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.