Evidence map›Paper›PMID 42609223›Full record

ArticleFrontiers in nutrition2026

Low referral uptake, not patient adherence, limits implementation of early nutritional screening in head and neck and upper gastrointestinal cancers.

Irene Azzali, Debora Guerra, Monia Suzzi, Alessandro Passardi, Sebastiano Calpona, Ilario Giovanni Rapposelli, Margherita Muratore, Francesco De Rosa, Elisabetta Parisi, Roberta Volpi and 1 more

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Irene AzzaliIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Debora GuerraIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Monia SuzziIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Alessandro PassardiIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Sebastiano CalponaIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Ilario Giovanni RapposelliIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Margherita MuratoreIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Francesco De RosaIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Elisabetta ParisiIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Roberta VolpiIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Patrizia SerraIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Malnutrition is highly prevalent in patients with head and neck and upper gastrointestinal cancers and is associated with poorer clinical outcomes. Despite guideline recommendations, early nutritional screening remains inconsistently implemented in routine oncology care. Methods: This single-center prospective feasibility study evaluated the implementation of an early nutritional screening and intervention pathway in newly diagnosed oncology patients with head and neck and upper gatrointestinal cancers. Eligible patients were enrolled within 7 days of their first oncology consultation and entered a structured nutritional pathway including baseline (T0), one-month (T1), and two-month (T2) assessments. Nutritional evaluation included MUST screening, anthropometric measures, bioelectrical impedance analysis, handgrip strength, biochemical parameters, and patient-reported outcomes (ESAS and FACT-G). Feasibility endpoints included referral, enrolment, and adherence rates. Results: Among 550 eligible patients, 77 were enrolled (14%). Once enrolled, adherence to the pathway was high (91%). At baseline, 47% of patients were classified as at high nutritional risk. Serum biochemical markers, available in a subset of patients, were consistent with mild nutritional alterations. During follow-up, body weight, handgrip strenght, biochemical and bioelectrical impedance parameters, and overall quality of life remained stable. Significant improvements were observed in selected symptoms, including fatigue, nausea, and well-being/malaise. Conclusion: Early nutritional screening is feasible and highly acceptable once implemented. However, implementation at the population level is limited by low and non-systematic referral rates, highlighting a critical gap in routine oncology care.

Indexed as

head and neck cancerimplementationmalnutritionnutritional screeningsupportive care

Identifiers

PMID42609223
PMCPMC13477941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.