Evidence map›Paper›PMID 42609189›Full record

ArticleFrontiers in medicine2026

Case Report: When benign overgrowth turns fatal in CLOVES syndrome: underestimated perioperative risk.

Yuheng Cui, Yang Liu, Guoliang Shi, Ning Wang, Yueqiao Xu, Xin Qu, Hao Zhao, Meng Qi, Weitao Cheng, Wenjin Chen and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Yuheng Cui *Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.
Yang Liu *Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Guoliang ShiDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.
Ning WangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.
Yueqiao XuDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.
Xin QuDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.
Hao ZhaoDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.
Meng QiDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.
Weitao ChengDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.
Wenjin ChenDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.
Lidan JiangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.
Tao LiuDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.
Rongcai JiangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CLOVES syndrome is driven by somatic activating PIK3CA mutations that constitutively activate the PI3K-AKT-mTOR pathway, resulting in segmental overgrowth and complex vascular malformations. Emerging evidence suggests these vascular lesions are biologically active and may pre-dispose to localized intravascular coagulation and thrombosis. We report a 21-year-old man with genetically confirmed CLOVES syndrome who developed concurrent consumptive coagulopathy and hypercoagulability. Post-operatively, he experienced both hemorrhagic and thromboembolic complications, culminating in fatal cardiac arrest. This case highlights a fragile perioperative hemostatic balance in CLOVES syndrome, underscoring the need for careful risk stratification and multidisciplinary management.

Indexed as

CLOVES syndromecoagulation abnormalitiesmultidisciplinary managementperioperative riskvascular malformations

Identifiers

PMID42609189
PMCPMC13477906

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.