Evidence map›Paper›PMID 42609165›Full record

ArticleEuropean journal of immunology2026

Analysis of Human Thymopoiesis Reveals Rapid Postnatal Remodeling of Thymocytes Within the First 3 Months of Life.

Camille Kergaravat, Jean-Marc Doisne, Clarisse Godard, Agata Cieslak, Mourad Amrane, David Vermijlen, Vahid Asnafi, Kamel Benlagha, James P Di Santo, Emmanuel Clave and 1 more

Abstract read
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In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Camille KergaravatInstitut de Recherche Saint Louis, INSERM UMR 1342, Université Paris Cité, Paris, France.
Jean-Marc DoisneInnate Immunity Unit, Institut Pasteur, INSERM U1223, Université Paris Cité, Paris, France.
Clarisse GodardInstitut de Recherche Saint Louis, INSERM UMR 1342, Université Paris Cité, Paris, France.
Agata CieslakLaboratoire d'Onco-Hématologie, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Mourad AmraneService De Chirurgie Cardiovasculaire, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
David VermijlenDepartment of Pharmacotherapy and Pharmaceutics, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Vahid AsnafiLaboratoire d'Onco-Hématologie, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Kamel BenlaghaInstitut de Recherche Saint Louis, INSERM UMR 1342, Université Paris Cité, Paris, France.
James P Di SantoInnate Immunity Unit, Institut Pasteur, INSERM U1223, Université Paris Cité, Paris, France.
Emmanuel ClaveInstitut de Recherche Saint Louis, INSERM UMR 1342, Université Paris Cité, Paris, France.
Antoine ToubertInstitut de Recherche Saint Louis, INSERM UMR 1342, Université Paris Cité, Paris, France.

Funding

French government's Investissement d'Avenir Program, Laboratoire d'Excellence "Milieu Intérieur" ANR-10-LABX-69-01French National Research Agency Hu-Thy-L-ANR-21-CE15-0008-01French National Research Agency (ANR) through the Epi-Tinn project ANR-25-CE15-5339-02Institut de la Leucémie Paris Saint-Louis ANR-23-IAHU-0005Université Paris Cité under its "Initiative of Excellence" IdEx program ANR-18-IDEX-0001Welbio investigator program WELBIO-CR-2022A-15
6 · The paper itself

Abstract

The thymus generates a diverse and self-tolerant T-cell repertoire. Its development and output undergo profound changes from fetal to early postnatal life, yet the dynamics of this transition remain incompletely understood. Here, we performed a comprehensive analysis of human thymopoiesis across the perinatal (birth to <10 days), early postnatal (10 days-3 months), and homeostasis (>3 months) periods using high-dimensional flow cytometry and signal joint T-cell receptor excision circle (sjTREC) quantification. Within the perinatal phase, the thymus exhibits the highest intrathymic production, with elevated frequencies of CD4

Indexed as

LymphopoiesisThymocytesThymus GlandCD4-Positive T-LymphocytesCell DifferentiationFemaleFlow CytometryHomeostasisHumansInfantInfant, NewbornT-Lymphocytes, Regulatoryperinatal immunitypostnatal immune developmentthymopoiesisunconventional T cells

Identifiers

PMID42609165
PMCPMC13482440

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.