Evidence map›Paper›PMID 42609043›Full record

ArticleEuropean journal of immunology2026

Ryanodine Receptor 1 Is Dispensable for CD4

Sogol Dostiar Tabrizi, Mikolaj Nawrocki, Tanja Bedke, Marius Böttcher, Friederike Stumme, Melina Birus, Franziska Möckl, Lola Hernandez, Björn-Phillip Diercks, Nicola Gagliani and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sogol Dostiar TabriziSection of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Mikolaj NawrockiSection of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tanja BedkeSection of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marius BöttcherSection of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Friederike StummeSection of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Melina BirusHamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Franziska MöcklThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lola HernandezThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Björn-Phillip DiercksThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nicola GaglianiHamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Dmitri LodyginInstitute For Neuroimmunology and Multiple Sclerosis Research, University Medical Center Göttingen, Germany.
Alexander FlügelInstitute For Neuroimmunology and Multiple Sclerosis Research, University Medical Center Göttingen, Germany.
Andreas H GuseThe Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hans-Willi MittrückerHamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Samuel HuberSection of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Funding

Deutsche Forschungsgemeinschaft projectnumberFKZ335447717Deutsche Forschungsgemeinschaft SFB1328
6 · The paper itself

Abstract

T-cell receptor (TCR) signaling is necessary for the activation and differentiation of CD4

Indexed as

CD4-Positive T-LymphocytesColitisRyanodine Receptor Calcium Release ChannelT-Lymphocyte SubsetsAnimalsCalcium SignalingCD3 ComplexCell DifferentiationChronic DiseaseDisease Models, AnimalLymphocyte ActivationMiceMice, KnockoutReceptors, Antigen, T-CellTh1 CellsTh2 CellsCD3 ComplexReceptors, Antigen, T-Cellryanodine receptor 1, mouseRyanodine Receptor Calcium Release Channelcalcium signalingCD4+ T‐cell differentiationCD4+ T cellsintestinal inflammationryanodine receptor 1

Identifiers

PMID42609043
PMCPMC13482298

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.