Evidence map›Paper›PMID 42609038›Full record

ArticleEuropean journal of immunology2026

Rapid and Highly Efficient CRISPR-Cas9 RNP Genome Editing in Primary ILC2s.

Arianna Maria Candelotti, Giordana Garzillo, Sara Bartolini, Chiara Di Censo, Giovanna Peruzzi, Helena Stabile, Cinzia Fionda, Giuseppe Sciumè, Giuseppe Pietropaolo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arianna Maria CandelottiDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
Giordana GarzilloDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
Sara BartoliniDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
Chiara Di CensoDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
Giovanna PeruzziCenter for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Rome, Italy.
Helena StabileDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
Cinzia FiondaDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
Giuseppe SciumèDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
Giuseppe PietropaoloDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.

Funding

Next Generation EU-PNRR M6C2 - Investimento 2.1 Valorizzazione e potenziamento della ricerca biomedica del SSNthe Italian Association for Cancer Research (AIRC)-Investigator Grant "Mirella Rizzo" IG-28719the Italian Association for Cancer Research (AIRC)-Investigator Grant "Mirella Rizzo" PNRR-MAD-2022-12375947
6 · The paper itself

Abstract

CRISPR-mediated gene editing enables efficient genetic manipulation of ILC2s through ex vivo or in vivo activation and Cas9 RNP delivery. This platform provides a robust approach to dissect gene function in ILC2s, with minimal manipulation.

Indexed as

CRISPR-Cas SystemsRibonucleoproteinsAnimalsHumansMiceRibonucleoproteins

Identifiers

PMID42609038
PMCPMC13482127

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.