Evidence map›Paper›PMID 42608963›Full record

ArticleCritical care explorations2026

Clinical Subphenotypes and Short-Term Outcomes in PICU Patients Receiving Continuous Blood Purification.

Kaizong Huang, Jiahua Ke, Zhiyuan Wang, Xuhua Ge, Zhe Zhao, Feiyan Chen, Lei Zhang, Jingwen Ni, Jing Zhao, Senquan Liang and 9 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

19 authors.

Kaizong HuangDepartment of Pharmacy, Nanjing First Hospital, China Pharmaceutical University, Nanjing, China.
Jiahua KeDepartment of Pharmacy, Nanjing First Hospital, China Pharmaceutical University, Nanjing, China.
Zhiyuan WangThe First Affiliated Hospital of Henan Medical University, Weihui, China.
Xuhua GePediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China.
Zhe ZhaoPediatric Intensive Care Unit, Faculty of Pediatrics, the Seventh Medical Center of Chinese People's Liberation Army General Hospital, Beijing, China.
Feiyan ChenDepartment of PICU, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Lei ZhangShenzhen Children's Hospital, Shenzhen, China.
Jingwen NiLuoyang Maternal and Child Health Hospital, Luoyang, China.
Jing ZhaoThe Second People's Hospital of Nanyang City, Nanyang, China.
Senquan LiangBoai Hospital of Zhongshan, Zhongshan, China.
Shengxin ZhangChildren's Hospital of Fudan University (Xiamen Branch), Xiamen Children's Hospital, Xiamen, China.
Qiang QuThe First People's Hospital of Chenzhou, Chenzhou, China.
Hui SunThe Affiliated Hospital of Guizhou Medical University, Guizhou, China.
Puyi WangAnyang Maternal and Child Health Care Hospital, Anyang, China.
Nan GongHandan Central Hospital, Handan, China.
Hongxia ShenYinchuan Maternal and Child Health Care Hospital, Yinchuan, China.
Jiangwei ZhuYellow River Sanmenxia Hospital, Sanmenxia, China.
Hongwei FanDepartment of Pharmacy, Nanjing First Hospital, China Pharmaceutical University, Nanjing, China.
Shujun LiThe First Affiliated Hospital of Henan Medical University, Weihui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo characterize clinical heterogeneity among PICU patients receiving continuous blood purification (CBP) and identify data-driven subphenotypes associated with distinct short-term outcomes.

designMulticenter, retrospective cohort study.

settingFifteen PICUs (from January 2019 to August 2024). PATIENTS: Children (1 mo to 18 yr) receiving CBP during PICU hospitalization.

interventionsNone. MEASUREMENTS AND MAIN

resultsIn this multicenter cohort of 598 CBP-treated children, unsupervised clustering at CBP initiation identified three reproducible subphenotypes using a seven-variable signature comprising aspartate aminotransferase, hemoglobin, oxygenation index, Pediatric Logistic Organ Dysfunction-2 score, procalcitonin, weight, and pH. These subphenotypes showed distinct multidomain physiologic profiles rather than a simple severity gradient. Subphenotype I had the most favorable short-term survival profile, subphenotype II had the poorest survival, and subphenotype III showed an intermediate pattern, with significant separation in 28-day survival across groups. Subphenotypes also differed in ICU length of stay, and exploratory analyses suggested subphenotype-dependent associations between high-volume hemofiltration exposure and ICU discharge. Cross-validated supervised models showed high discriminability of subphenotype assignment.

conclusionsCBP-treated children exhibited distinct subphenotypes at CBP initiation with divergent short-term prognoses, highlighting marked heterogeneity at this treatment stage. Subphenotype-based stratification may support risk characterization and trial enrichment and facilitate hypothesis generation regarding heterogeneity of treatment associations. Prospective validation is warranted.

Indexed as

Continuous Renal Replacement TherapyIntensive Care Units, PediatricAdolescentChildChild, PreschoolFemaleHumansInfantMalePhenotypeRetrospective Studiesclinical subphenotypesmachine learningpediatric intensive careprecision medicinerenal replacement therapy

Identifiers

PMID42608963
PMCPMC13485852

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.