SynthesisCancer medicine2026
Mediterranean Diet and Risk of Pancreatic Cancer-Is It Worth Investigating More? An Updated Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
Synthesis in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
backgroundDespite previous meta-analysis studies on the association between adherence to the Mediterranean diet and risk of pancreatic cancer, there has not been a comprehensive and updated study reviewing all studies with inclusion criteria. Despite advances in cancer treatment and control, pancreatic cancer is still one of the deadliest malignancies, and the mortality rate is consistent with its prevalence. Therefore, this updated systematic review and dose-response meta-analysis study was conducted to examine the association between one of the healthiest dietary patterns, the Mediterranean dietary pattern, and the rate of pancreatic cancer.
methodsUsing relevant keywords, electronic searches for prospective cohort studies were conducted in Web of Science, PubMed, and Scopus until March 17, 2025. The reported hazard ratios (HRs) in the primary studies were regarded as the main effect size. The overall effect was calculated using a random-effects model that accounts for between-study variability.
resultsBased on 10 prospective studies, we found that people who adhered more strictly to the Mediterranean diet had a lower risk of developing pancreatic cancer (pooled HR: 0.90; CI: 0.82-0.98; I
conclusionThe present systematic review and dose-response meta-analysis of prospective cohort studies provides compelling evidence for an inverse relationship between adherence to the Mediterranean diet and the risk of pancreatic cancer. REGISTRY AND REGISTRY NUMBER FOR SYSTEMATIC REVIEWS OR META-ANALYSES: The study's protocol was registered in the international prospective registry of systematic reviews (URL: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=423150 and Registration ID: CRD42023423150).
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