Combined bioactive PVA nanofibrous scaffolds loaded with Zn ascorbate MOFs and Petroselinum crispum (Parsley) extract for enhanced in-vitro and in-vivo wound healing applications.

Shimaa Husien, Rana R Haikal, Eman A Khalil, Noha El Salakawy, Ahmed Abdellatif, Wael Mamdouh

Abstract read

In one paragraph

Article in Journal of biological engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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5 · Who and what money

Authors and funding

6 authors.

Shimaa HusienDepartment of Chemistry, School of Sciences and Engineering (SSE), The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo, 11835, Egypt.

Rana R HaikalDepartment of Chemistry, School of Sciences and Engineering (SSE), The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo, 11835, Egypt.

Eman A KhalilDepartment of Biology, School of Sciences and Engineering, The American University in Cairo (AUC), P.O. Box 74, AUC Avenue, New Cairo, 11835, Egypt.

Noha El SalakawyDepartment of Chemistry, School of Sciences and Engineering (SSE), The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo, 11835, Egypt.

Ahmed AbdellatifDepartment of Biology, School of Sciences and Engineering, The American University in Cairo (AUC), P.O. Box 74, AUC Avenue, New Cairo, 11835, Egypt.

Wael MamdouhDepartment of Chemistry, School of Sciences and Engineering (SSE), The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo, 11835, Egypt. wael_mamdouh@aucegypt.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wounds damage the skin, mucosal membranes, or underlying tissues, disrupting normal structure and function. Natural therapeutic agents, particularly plant extracts, have been widely used in wound management due to their antimicrobial and regenerative properties. Here, we report a novel multifunctional wound dressing by integrating Petroselinum crispum (parsley, PS) extract and zinc ascorbate-based metal-organic frameworks (MOFs) into a polyvinyl alcohol (PVA) nanofibrous matrix. The resulting MOF/PS-loaded PVA nanofibers (NFs) combine biodegradability, biocompatibility, and enhanced bioactivity for wound healing. The optimized formulation (PVA/MOF5/PS30-NFs) exhibited strong antibacterial activity, with inhibition zones of ~ 250 mm², total phenolic content of 1.41 mg GAE/g, and antioxidant IC₅₀ values of 15.17 and 11.11 mg/3mL at 2 and 24 h, respectively. Cytocompatibility tests confirmed excellent cell viability (> 100%). In-vitro assays demonstrated enhanced fibroblast migration and edge contraction, with substantial wound closure after 48 h. In-vivo studies showed complete (> 100%) wound closure by day 15, surpassing controls (~ 80%), with the fastest healing trajectory and early acceleration phase observed. To our knowledge, this is the first report of this composition and application. These findings highlight MOF/PS-loaded PVA nanofibrous mats as a promising platform for advanced wound-healing therapies. CLINICAL

trial registrationNot applicable.

Indexed as

AntibacterialMOFNanofibersParsleyScaffoldsWound healing

Identifiers

PMID42608701

DOI10.1186/s13036-026-00736-8

PMCPMC13479814

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.