ArticleEuropean archives of psychiatry and clinical neuroscience2026
Altered seed-to-whole-brain functional connectivity of goal-directed/habitual systems in obsessive-compulsive disorder: associated genes and preliminary classification potential.
Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
objectiveThis study aimed to investigate the whole-brain functional connectivity (FC) patterns of goal-directed/habitual systems in patients with obsessive-compulsive disorder (OCD), and to explore their exploratory classification potential and spatial associations with gene expression profiles.
methodsResting-state functional magnetic resonance imaging (fMRI) data and clinical variables were collected from 60 patients with OCD and 60 matched healthy controls (HCs). Seed-to-whole-brain FC analyses were conducted using the regions of interest (ROIs) implicated in goal-directed/habitual systems. Pearson correlation analyses were conducted to assess the associations between altered FCs and clinical characteristics. An exploratory support vector machine (SVM) analysis was utilized to evaluate whether altered FC patterns could distinguish patients with OCD from HCs, and neuroimaging-transcriptomic analysis was performed to investigate the spatial association between aberrant FCs and gene expression profiles.
resultsCompared to HCs, patients with OCD exhibited decreased FCs between goal-directed system and the default mode network (DMN) and central executive network (CEN), as well as between habitual system and salience network (SN). Conversely, increased FCs were observed between habitual system and DMN. No significant correlations were observed between altered FCs and clinical characteristics after multiple-comparison correction. Exploratory SVM analysis indicated that altered FC patterns of goal-directed system showed higher classification performance (accuracy = 90.83%, AUC = 0.951) than those of the habitual system (accuracy = 79.17%, AUC = 0.867). Imaging-transcriptomic analysis revealed that regional FC alterations were spatially associated with gene (i.e., PPARD and SLC25A12), which were enriched in transmembrane ion transport and metal ion homeostasis.
conclusionOCD exhibited altered FCs patterns between goal-directed/habitual systems and the triple networks at rest. These findings may provide more information to understand the pathology of OCD.
Indexed as
Identifiers
42608583What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.