Evidence map›Paper›PMID 42608571›Full record

ArticleNature neuroscience2026

Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence.

Xin Yan, Christina Georgopoulou, Hang-Mao Lee, Ala Ahrari, Jenny Russ, Vijay Chandrasekar, Tim Ducksch, Giuliano Crispatzu, Valentina Talevi, Liang Qiao and 36 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Xin Yan *Nuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. xin.yan@dzne.de.ORCID http://orcid.org/0000-0002-9135-7915
Christina Georgopoulou *Nuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Hang-Mao Lee *Nuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Ala AhrariNuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0001-7793-0060
Jenny RussNuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Vijay ChandrasekarNuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0002-5452-5107
Tim DuckschNuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Giuliano CrispatzuNuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Valentina TaleviPopulation Health Sciences, DZNE and Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-4418-7439
Liang QiaoCollaborative Innovation Center of Stem Cell and Biotherapy, Henan Medical University, Xinxiang, China.ORCID http://orcid.org/0000-0002-8765-8491
Shobhit AgrawalPlatform for Single Cell Genomics and Epigenomics (PRECISE), DZNE and University of Bonn, Bonn, Germany.
Sophie CruxNeuroimmunology and Imaging Group, DZNE, Bonn, Germany.
Andrew W DamanImmunology and Microbial Pathogenesis Program, Department of Pathology and Laboratory Medicine, Division of Cell and Cancer Pathobiology, Weill Cornell Medicine Graduate School of Medical Sciences, New York, NY, USA.
Lena WischhofAging and Neurodegeneration Group, DZNE, Bonn, Germany.
Miriam StorkNuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Margit ZweyerNuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Emma Dorotea ZanfiNuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Manon Chevallot-BerouxNuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Yunxiao LiTranslational Neurodegeneration Section 'Albrecht Kossel', University Medical Center Rostock, University of Rostock, Rostock, Germany.ORCID http://orcid.org/0009-0006-6992-9098
Elena De-DomenicoPlatform for Single Cell Genomics and Epigenomics (PRECISE), DZNE and University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-0336-8284
Dina HüssonImmunogenomic and Neurodegeneration Group, DZNE, Bonn, Germany.
Lorenzo BonaguroPlatform for Single Cell Genomics and Epigenomics (PRECISE), DZNE and University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-9675-7208
Yuanfang LiImmunogenomic and Neurodegeneration Group, DZNE, Bonn, Germany.
Jonas Schulte-SchreppingPlatform for Single Cell Genomics and Epigenomics (PRECISE), DZNE and University of Bonn, Bonn, Germany.
Qingyi LiangDepartment of Cancer Biology, University College London (UCL) Cancer Institute, University College London, London, UK.
Ketty KesslerDepartment of Cancer Biology, University College London (UCL) Cancer Institute, University College London, London, UK.
Dan EhningerTranslational Biogerontology Group, DZNE, Bonn, Germany.ORCID http://orcid.org/0000-0001-7464-1335
Shahin RafiiDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-5605-1067
Jiankai LuoTranslational Neurodegeneration Section 'Albrecht Kossel', University Medical Center Rostock, University of Rostock, Rostock, Germany.ORCID http://orcid.org/0000-0001-5169-3095
Andreas HermannTranslational Neurodegeneration Section 'Albrecht Kossel', University Medical Center Rostock, University of Rostock, Rostock, Germany.ORCID http://orcid.org/0000-0002-7364-7791
Annett HalleMicroglia and Neuroinflammation, DZNE, Bonn, Germany.
Ying LiuDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Elvira MassLife and Medical Sciences (LIMES) Institute, Developmental Biology of the Immune System, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-2318-2356
Melania CapassoImmune Regulation Group, DZNE, Bonn, Germany.ORCID http://orcid.org/0000-0001-8659-9867
Hiroki KatoInstitute of Cardiovascular Immunology, University Hospital Bonn, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-9571-4895
Joachim L SchultzePlatform for Single Cell Genomics and Epigenomics (PRECISE), DZNE and University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-2812-9853
Pierluigi NicoteraSynaptic Connectivity and Neurodegeneration Group, DZNE, Bonn, Germany.
Daniele BanoAging and Neurodegeneration Group, DZNE, Bonn, Germany.ORCID http://orcid.org/0000-0002-9617-5504
Steven Zvi JosefowiczImmunology and Microbial Pathogenesis Program, Department of Pathology and Laboratory Medicine, Division of Cell and Cancer Pathobiology, Weill Cornell Medicine Graduate School of Medical Sciences, New York, NY, USA.ORCID http://orcid.org/0000-0001-7453-779X
Martin FuhrmannNeuroimmunology and Imaging Group, DZNE, Bonn, Germany.ORCID http://orcid.org/0000-0001-7672-2913
Thomas UlasPlatform for Single Cell Genomics and Epigenomics (PRECISE), DZNE and University of Bonn, Bonn, Germany.
Marc BeyerPlatform for Single Cell Genomics and Epigenomics (PRECISE), DZNE and University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-9704-148X
Juntang LinCollaborative Innovation Center of Stem Cell and Biotherapy, Henan Medical University, Xinxiang, China.
Monique M B BretelerPopulation Health Sciences, DZNE and Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-0626-9305
N Ahmad AzizPopulation Health Sciences, DZNE and Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-6184-458X
Paolo SalomoniNuclear Function Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. paolo.salomoni@dzne.de.ORCID http://orcid.org/0000-0001-6885-8116

Funding

Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) FKZ:01KX2230Deutsche Forschungsgemeinschaft (German Research Foundation) LU 1455/6-1Deutsche Forschungsgemeinschaft (German Research Foundation) YA721/3-1
6 · The paper itself

Abstract

Aging-associated loss of chromatin compaction is linked to derepression of retrotransposable elements (RTEs) in mouse and human tissues. Whether such RTE transcription contributes to the microglia activation that is common in aged brains is unknown. Here, we show that DAXX, a histone chaperone and RTE repressor, is downregulated during aging, preserves microglia homeostasis and inhibits cellular senescence. Loss of Daxx in young-adult microglia drives a reactive phenotype marked by chromatin decompaction at RTEs, loss of homeostatic markers, cell cycle re-entry and behavioral changes. This state leads to DNA damage and microglial depletion, followed by replacement with DAXX-deficient/Apoe

Indexed as

Cellular SenescenceEndogenous RetrovirusesInflammationMicrogliaAdaptor Proteins, Signal TransducingAgingAnimalsCo-Repressor ProteinsMiceMice, Inbred C57BLMolecular ChaperonesNuclear ProteinsAdaptor Proteins, Signal TransducingCo-Repressor ProteinsMolecular ChaperonesNuclear Proteins

Identifiers

PMID42608571
PMCPMC13633122

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.