ArticleCurrent microbiology2026
Bbsmf1, an Nramp Family Transporter, Sustains Iron Homeostasis Through Cross Pathway Compensation in Beauveria bassiana.
Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Iron homeostasis is essential for the survival and pathogenesis of entomopathogenic fungi, yet the mechanisms underpinning its network resilience remain largely unknown. In this study, we characterize BbSmf1, the sole Nramp‑family transporter in the biocontrol fungus B. bassiana. Unlike the multiple paralogs found in yeast, B. bassiana possesses a streamlined Smf‑mediated pathway. We show that BbSMF1 is strongly induced under iron‑deficient conditions and is directly regulated by the core transcription factor BbHapX. Although deletion of BbSMF1 did not impair growth or virulence under standard conditions, it triggered a massive compensatory transcriptional surge-up to 109‑fold-in genes associated with the reductive iron‑uptake system (e.g., BbFREs and BbFTRs). Moreover, the ΔBbsmf1 mutant exhibited significantly reduced intracellular Fe
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