ReviewPediatric research2026
Nutritional management at 22-23 weeks gestational age: evidence and knowledge gaps.
Review in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With advancing medical capabilities, survival of infants born at 22-23 weeks' gestation is increasing. However, specific recommendations for nutrition support for these infants are lacking. This review examines the unique characteristics of infants born at 22-23 weeks' gestation that impact parenteral and enteral nutrition support, highlighting the lack of evidence and knowledge gaps for optimal practices. Current recommendations developed for extremely or very low birth weight infants may be unsuitable for infants born at 22-23 weeks' gestation due to important differences in anatomy, physiology, body composition, and metabolic capabilities. Key challenges include severely limited intraluminal digestion, profound immune and microbiome immaturity, and reduced metabolic tolerance to parenteral nutrition provision based on current recommendations, none of which are addressed by recommendations developed for larger, more mature preterm populations. Until more specific studies for infants 22-23 weeks gestation are conducted, clinicians must carefully tailor nutritional support for this vulnerable population given their functional and maturational limitations. IMPACT: Survival of infants born at 22-23 weeks gestation is increasing, but currently available nutrition support recommendations may be inadequate due to the unique physiological, metabolic, and gastrointestinal characteristics that are not accounted for in current parenteral and enteral nutrition support recommendations. This review synthesizes available evidence and identifies critical knowledge gaps in nutrition support management specific to infants born at 22-23 weeks' gestation. We provide a framework to guide individualized clinical decision-making and establish research priorities and collaborative efforts in infants born at 22-23 weeks' gestation.
Identifiers
42608540What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.