Evidence map›Paper›PMID 42608525›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Altered thalamo-prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition.

Sofiya Hupalo, David A Kupferschmidt, Ako Ikegami, Mia Railing, Maxym V Myroshnychenko, Gabriel Loewinger, Francisco Pereira, Joseph A Gogos, Joshua A Gordon

Abstract read
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In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sofiya Hupalo *Integrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5719-1886
David A Kupferschmidt *Integrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-9406-7681
Ako IkegamiIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Mia RailingIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Maxym V MyroshnychenkoIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Gabriel LoewingerMachine Learning Team, National Institute of Mental Health, Bethesda, MD, USA.
Francisco PereiraMachine Learning Team, National Institute of Mental Health, Bethesda, MD, USA.
Joseph A GogosZuckerman Institute, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-7491-4476
Joshua A GordonIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. joshua.gordon@nyspi.columbia.edu.ORCID http://orcid.org/0000-0002-5488-8266

Funding

U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) FI2-GM133387U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) ZIC-MH002968
6 · The paper itself

Abstract

Schizophrenia is associated with profound working memory deficits, for which there are no approved treatments. Rare heterozygous null mutations in SETD1A, a gene encoding a key epigenetic regulator, have been definitively linked to increased risk for schizophrenia and neurodevelopmental disorders. To investigate how SETD1A haploinsufficiency impacts the function of circuits supporting working memory, this study examined neural oscillatory synchrony across a network of brain regions critical for spatial working memory (SWM) in mice carrying a loss-of-function allele in the orthologous Setd1a gene. Local field potential recordings were performed in the prefrontal cortex, dorsal and ventral hippocampus, and thalamic nucleus reuniens in male and female wildtype and Setd1a

Identifiers

PMID42608525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.