Evidence map›Paper›PMID 42608502›Full record

ArticleThe AAPS journal2026

Design, Optimization and Evaluation of Taste-Masked Acemetacin Formulations Using Purolite A430MR.

Xinyi Shi, Yanfei Wang, Zhaohua Li, Sining Han, Jirun Jia, Yibo Li, Qiang Fu

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Article in The AAPS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinyi Shi *Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.ORCID http://orcid.org/0009-0006-4894-8206
Yanfei Wang *Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.ORCID http://orcid.org/0009-0000-6031-9214
Zhaohua LiWuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.ORCID http://orcid.org/0009-0000-1599-4288
Sining HanWuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.ORCID http://orcid.org/0009-0008-1833-489X
Jirun JiaSchool of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.ORCID http://orcid.org/0009-0007-0450-0239
Yibo LiWuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.ORCID http://orcid.org/0009-0008-0499-0036
Qiang FuWuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China. fuqiang@syphu.edu.cn.ORCID http://orcid.org/0000-0003-4076-5609

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A favorable taste is highly desirable for oral formulations, as an unpleasant bitter taste can severely compromise patient compliance. Acemetacin (ACM) is a bitter and poorly soluble drug, posing a significant challenge for oral administration. In this study, Purolite A430MR (A430MR) was employed to mask the bitterness of ACM via a precipitation method, forming ACM-A430MR resin composites (ARCs). A 1:1 weight ratio of ACM to A430MR was identified as the optimized formulation, achieving favorable drug loading and process yield. The ARCs

Indexed as

TasteAdministration, OralChemistry, PharmaceuticalDrug DesignDrug LiberationHumansMolecular Docking SimulationSolubilityAcemetacinAmorphousIon exchange resinPurolite A430MRTaste masking

Identifiers

PMID42608502

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.