Evidence map›Paper›PMID 42608467›Full record

ArticleNature human behaviour2026

Parental haplotype reconstruction in up to 440,209 UK and Estonian individuals reveals recent assortative mating dynamics.

Robin J Hofmeister, Davide Marnetto, Théo Cavinato, Leona Knüsel, Giorgia Modenini, Erwan Pennarun, Estonian Biobank Research Team, Nicola Barban, Reedik Mägi, Tabea Schoeler and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature human behaviour, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Robin J HofmeisterDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland. robin.j.hofmeister@gmail.com.ORCID http://orcid.org/0000-0002-9965-595X
Davide MarnettoDepartment of Neurosciences, University of Turin, Turin, Italy.ORCID http://orcid.org/0000-0001-9573-0601
Théo CavinatoDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0009-0003-9916-5525
Leona KnüselDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Giorgia ModeniniDepartment of Neurosciences, University of Turin, Turin, Italy.ORCID http://orcid.org/0000-0003-0227-9765
Erwan PennarunEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Estonian Biobank Research Team
Nicola BarbanDepartment of Statistical Sciences, University of Bologna, Bologna, Italy.
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-2964-6011
Tabea SchoelerDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-4846-2741
Luca PaganiDepartment of Biology, University of Padova, Padova, Italy.
Zoltán KutalikDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland. zoltan.kutalik@unil.ch.ORCID http://orcid.org/0000-0001-8285-7523

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030-189147Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 315230-219587
6 · The paper itself

Abstract

Assortative mating (AM), the tendency to choose partners with similar traits, contributes to the genetic architecture of human traits. Detecting its genetic footprint (genetic AM) requires either genotyped couples or detection of gametic phase disequilibrium (which is insensitive to recent changes). We introduce an inter-chromosomal phasing approach that reconstructs parental haplotypes from close relatives and correlates maternally and paternally inherited polygenic scores to provide estimates enriched for recent AM. Applied to 69 traits in 245,884 UK Biobank and 194,325 Estonian Biobank individuals, our approach showed concordance with mate-pair-based estimates comparable to or better than existing approaches, significantly outperforming them in the Estonian Biobank (through-origin r

Identifiers

PMID42608467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.